Table 4.
Characterization of SNEDDS formulations.
| Parameters | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| Drug content (%) | 96.78 ± 1.46 | 98.88 ± 1.53 | 98.46 ± 1.07 | 96.88 ± 1.86 | 102.34 ± 2.41 | 98.56 ± 1.97 |
| Self-emulsification time (sec) | 15 ± 1 | 18 ± 2 | 14 ± 1 | 9 ± 1 | 8 ± 1 | 6 ± 2 |
| Precipitation | Stable | Stable | Stable | Stable | Unstable | Unstable |
| Clarity | Bluish | Bluish | Bluish | Bluish | Turbid | Turbid |
| Viscosity (cps) | ||||||
| 0-time dilution | 353 | 364 | 326 | 324 | 321 | 302 |
| 10-time dilution | 1.17 | 1.16 | 1.15 | 1.13 | 1.12 | 1.08 |
| 100-time dilution | 0.888 | 0.883 | 0.88 | 0.863 | 0.857 | 0.843 |
| % transmittance | 55.73 | 81.43 | 71.23 | 57.41 | 61.54 | 56.32 |
| Droplet size (nm) | 98.48 ± 10.24 | 42.84 ± 13.78 | 151 ± 2.67 | 158.5 ± 15.32 | 117.5 ± 3.22 | 95.84 ± 5.42 |
| Zeta potential (mV) | −10.8 ± 0.11 | −15.4 ± 0.09 | −11.7 ± 0.23 | −12.3 ± 0.15 | −12 ± 0.18 | −13.6 ± 0.21 |