Table 2.
Case | Age at HL Diagnosis (y) | RT Regions and Total Dose | Age at Breast Cancer Diagnosis (y) | Detection Method | Screening Round at Time of Detection | Side | CBE | MMG | US | MRI | Type of Surgery | Histology | T | N | M | Grade | Tumor size (mm) | ER | PR | Her2 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 12 | Mantle 25Gy | 39 | MRI MMG | 3 | Left | Neg | Pos | Neg | Pos | Bilat Mx | DCIS | Tis | 0 | 0 | II | 10 | — | — | — |
2 | 15 | Mantle 15Gy | 31 | MRI | 1 | Left | Lump | Pos | n/a | Pos | Bilat Mx | IDC | T2 | 0 | 0 | II | 15 | Pos | Neg | Neg |
3 | 19 | Mantle + mediastinum 36 Gy | 34 | MMG | 1 | Left | n/a | Pos | n/a | Neg | Bilat Mx | DCIS | Tis | 0 | 0 | II | 3 | Pos | Pos | Equivocal |
4 | 12 | Mediastinum 25 Gy | 24 | MRI MMG | 3 | Right | n/a | Pos | Pos | Pos | Bilat Mx | IDC | T1a | 0 | 0 | II | 3 | Pos | Pos | Neg |
5 | 19 | Mantle + mediastinum 40Gy | 43 | MRI MMG | 1 | Left | n/a | Pos | Pos | Pos | Bilat Mx | DCIS | Tis | 0 | 0 | II | — | Pos | Pos | Neg |
6 | 18 | Mantle 30 Gy + mediastinum 40 Gy | 41 | MRI | 2 | Left | n/a | Neg | Pos | Pos | Bilat Mx | IDC | T1b | 0 | 0 | III | 4 | Neg | Neg | Neg |
7 | 19 | Mantle 36 Gy + mediastinum 42 Gy | 40 | MRI MMG | 3 | Right | n/a | Pos | Pos | Pos | Bilat Mx | IDC | T1b | 0 | 0 | III | 8 | Neg | Neg | Neg |
8 | 19 | Mantle + mediastinum 40 Gy | 40 | MMG | 4 | Right | n/a | Pos | n/a | Neg | Bilat Mx | DCIS | Tis | 0 | 0 | II | — | Pos | Pos | Neg |
9 | 18 | Mantle 30 Gy + mediastinum 40 Gy | 32 | MRI | 1 | Right | n/a | Neg | Neg | Pos | Right Mx | DCIS | Tis | 0 | 0 | II | 5 | Pos | Pos | Pos |
— | 36 | MRI MMG | 4 | Left | n/a | Pos | n/a | Pos | Left Mx | IDC | T1b | 0 | 0 | III | 10 | Neg | Neg | Neg |
Abbreviations: HL, Hodgkin's lymphoma; RT, radiotherapy; CBE, clinical breast examination; DCIS, ductal carcinoma in situ; Dx, diagnosis; IDC, invasive ductal carcinoma; MMG,= mammography; US, ultrasound; MRI, magnetic resonance imaging; TNM, TNM staging; Mx, right-sided mastectomy; Bilat, bilateral; n/a, not applicable; Neg, negative; Pos, positive.