Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1974 Jan;5(1):33–37. doi: 10.1128/aac.5.1.33

Cefoxitin, a Semisynthetic Cephamycin Antibiotic: In Vivo Evaluation

A Kathrine Miller 1, Evemarie Celozzi 1, Yulin Kong 1, Barbara A Pelak 1, David Hendlin 1, Edward O Stapley 1
PMCID: PMC428915  PMID: 4840448

Abstract

Cefoxitin, 3-carbamoyloxymethyl-7-α-methoxy-7-[2-(2-thienyl)acetamido]-3-cephem-4- carboxylic acid, a semisynthetic cephamycin antibiotic shown to have broad-spectrum activity in vitro, is active also in vivo against a wide variety of bacteria including penicillin-resistant staphylococci. It is, however, particularly effective against gram-negative organisms including strains of indole-positive Proteus against which cephalothin and cephaloridine are ineffective. When cefoxitin is given subcutaneously, concentrations in mouse blood, urine, and other tissues are higher than those seen for cephalothin. Higher concentrations in the blood and greater therapeutic efficacy are achieved with cefoxitin when it is given with probenecid. For this reason it is believed that cefoxitin is excreted mainly by way of the renal tubules. The data indicate that cefoxitin has potential as a therapeutically useful antibiotic.

Full text

PDF
33

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cama L. D., Leanza W. J., Beattie T. R., Christensen B. G. Substituted penicillin and cephalosporin derivatives. I. Stereospecific introduction of the C-6(7) methoxy group. J Am Chem Soc. 1972 Feb 23;94(4):1408–1410. doi: 10.1021/ja00759a089. [DOI] [PubMed] [Google Scholar]
  2. Goldner M., Glass D. G., Fleming P. C. Characteristics of Aerobacter beta-lactamase. Can J Microbiol. 1968 Feb;14(2):139–145. doi: 10.1139/m68-023. [DOI] [PubMed] [Google Scholar]
  3. Goldner M., Glass D. G., Fleming P. C. Spontaneous mutant with loss of beta-lactamase in Aerobacter cloacae. J Bacteriol. 1969 Feb;97(2):961–961. doi: 10.1128/jb.97.2.961-.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Karady S., Pines S. H., Weinstock L. M., Roberts F. E., Brenner G. S., Hoinowski A. M., Cheng T. Y., Sletzinger M. Semisynthetic cephalosporins via a novel acyl exchange reaction. J Am Chem Soc. 1972 Feb 23;94(4):1410–1411. doi: 10.1021/ja00759a090. [DOI] [PubMed] [Google Scholar]
  5. Kislak J. W., Steinhauer B. W., Finland M. Cephaloridine activity in vitro and absorption and urinary excretion in normal young men. Am J Med Sci. 1966 Apr;251(4):433–448. [PubMed] [Google Scholar]
  6. LEE C. C., HERR E. B., Jr, ANDERSON R. C. Pharmacological and toxicological studies on cephalotin. Clin Med (Northfield) 1963 Jun;70:1123–1138. [PubMed] [Google Scholar]
  7. Miller A. K., Celozzi E., Kong Y., Pelak B. A., Kropp H., Stapley E. O., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. IV. In vivo studies. Antimicrob Agents Chemother. 1972 Oct;2(4):287–290. doi: 10.1128/aac.2.4.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nagarajan R., Boeck L. D., Gorman M., Hamill R. L., Higgens C. E., Hoehn M. M., Stark W. M., Whitney J. G. Beta-lactam antibiotics from Streptomyces. J Am Chem Soc. 1971 May 5;93(9):2308–2310. doi: 10.1021/ja00738a035. [DOI] [PubMed] [Google Scholar]
  9. Onishi H. R., Daoust D. R., Zimmerman S. B., Hendlin D., Stapley E. O. Cefoxitin, a semisynthetic cephamycin antibiotic: resistance to beta-lactamase inactivation. Antimicrob Agents Chemother. 1974 Jan;5(1):38–48. doi: 10.1128/aac.5.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sabath L. D., Finland M. Resistance of penicillins and cephalosporins to beta-lactamases from Gram-negative bacilli: some correlations with antibacterial activity. Ann N Y Acad Sci. 1967 Sep 27;145(2):237–247. doi: 10.1111/j.1749-6632.1967.tb50222.x. [DOI] [PubMed] [Google Scholar]
  11. Stapley E. O., Jackson M., Hernandez S., Zimmerman S. B., Currie S. A., Mochales S., Mata J. M., Woodruff H. B., Hendlin D. Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n. Antimicrob Agents Chemother. 1972 Sep;2(3):122–131. doi: 10.1128/aac.2.3.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wallick H., Hendlin D. Cefoxitin, a semisynthetic cephamycin antibiotic: susceptibility studies. Antimicrob Agents Chemother. 1974 Jan;5(1):25–32. doi: 10.1128/aac.5.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES