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. 1974 Feb;5(2):101–105. doi: 10.1128/aac.5.2.101

Potentiation of the Antibacterial Effect of Methanamine by Acetohydroxamic Acid

Daniel M Musher 1,2,3, Donald P Griffith 1,2,3, Michael Tyler 1,2,3, Alan Woelfel 1,2,3
PMCID: PMC428928  PMID: 4840424

Abstract

In vitro testing shows nearly all strains of Proteus to be susceptible to methenamine. However, infection by urease-producing bacteria alkalinizes the urine in vivo and prevents generation of formaldehyde, the active metabolite, from methenamine. We have previously shown acetohydroxamic acid (AHA) to be an effective inhibitor of bacterial urease in vitro and in vivo. We now present data obtained by use of static and dynamic in vitro systems, which show that, by preventing urease-induced alkalinization of urine, AHA enables methenamine to exert its antibacterial effect against representative Proteus species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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