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. 1974 Mar;5(3):276–280. doi: 10.1128/aac.5.3.276

Treatment of Anaerobic Bacterial Infections with Clindamycin-2-Phosphate

Matthew E Levison 1, Jose L Bran 1, Kristen Ries 1
PMCID: PMC428960  PMID: 4600161

Abstract

Thirty-five patients with a variety of serious infections caused by anaerobic bacteria responded to clindamycin. Cure was achieved in 27 of the 32 patients with pleuropulmonary and intra-abdominal infections. Mean serum concentrations of clindamycin for the 8 h after intramuscular administration of clindamycin in these patients were at least 2.5 times the minimal inhibitory concentration of clindamycin for more than 90% of anaerobes. This experience suggests that clindamycin is an excellent and relatively safe antibiotic for treatment of infection caused by anaerobes when combined with surgery (when indicated) or other antibiotics active against aerobic gram-negative bacilli, if present.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartlett J. G., Sutter V. L., Finegold S. M. Treatment of anaerobic infections with lincomycin and clindamycin. N Engl J Med. 1972 Nov 16;287(20):1006–1010. doi: 10.1056/NEJM197211162872002. [DOI] [PubMed] [Google Scholar]
  2. Bodner S. J., Koenig M. G., Goodman J. S. Bacteremic Bacteroides infections. Ann Intern Med. 1970 Oct;73(4):537–544. doi: 10.7326/0003-4819-73-4-537. [DOI] [PubMed] [Google Scholar]
  3. Bodner S. J., Koenig M. G., Treanor L. L., Goodman J. S. Antibiotic susceptibility testing of Bacteroides. Antimicrob Agents Chemother. 1972 Aug;2(2):57–60. doi: 10.1128/aac.2.2.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cohen L. E., McNeill C. J., Wells R. F. Clindamycin-associated colitis. JAMA. 1973 Mar 19;223(12):1379–1380. [PubMed] [Google Scholar]
  5. Elmore M. F., Rink L. D., Rissing J. P. Clindamycin, endocarditis, hepatotoxicity. Ann Intern Med. 1973 May;78(5):779–780. doi: 10.7326/0003-4819-78-5-779_3. [DOI] [PubMed] [Google Scholar]
  6. Fass R. J., Saslaw S. Clindamycin: clinical and laboratory evaluation of parenteral therapy. Am J Med Sci. 1972 May;263(5):368–382. [PubMed] [Google Scholar]
  7. Fass R. J., Scholand J. F., Hodges G. R., Saslaw S. Clindamycin in the treatment of serious anaerobic infections. Ann Intern Med. 1973 Jun;78(6):853–859. doi: 10.7326/0003-4819-78-6-853. [DOI] [PubMed] [Google Scholar]
  8. GUNN A. A. Bacteroides septicaemia. J R Coll Surg Edinb. 1956 Sep;2(1):41–50. [PubMed] [Google Scholar]
  9. Gelb A. F., Seligman S. J. Bacteroidaceae bacteremia. Effect of age and focus of infection upon clinical course. JAMA. 1970 May 11;212(6):1038–1041. doi: 10.1001/jama.212.6.1038. [DOI] [PubMed] [Google Scholar]
  10. Haldane E. V., Van Rooyen C. E. Treatment of severe bacteroides infections with parenteral clindamycin. Can Med Assoc J. 1972 Dec 23;107(12):1177–1181. [PMC free article] [PubMed] [Google Scholar]
  11. Ingham H. R., Selkon J. B., Codd A. A., Hale J. H. The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro. J Clin Pathol. 1970 Apr;23(3):254–258. doi: 10.1136/jcp.23.3.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kislak J. W. The susceptibility of Bacteroides fragilis to 24 antibiotics. J Infect Dis. 1972 Mar;125(3):295–299. doi: 10.1093/infdis/125.3.295. [DOI] [PubMed] [Google Scholar]
  13. MCHENRY M. C., WELLMAN W. E., MARTIN W. J. Bacteremia due to Bacteroides. Review of 11 cases. Arch Intern Med. 1961 Apr;107:572–577. doi: 10.1001/archinte.1961.03620040098011. [DOI] [PubMed] [Google Scholar]
  14. Marcoux J. A., Zabransky R. J., Washington J. A., 2nd, Wellman W. E., Martin W. J. Bacteroides bacteremia. Minn Med. 1970 Nov;53(11):1169–1176. [PubMed] [Google Scholar]
  15. Martin W. J., Gardner M., Washington J. A., 2nd In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens. Antimicrob Agents Chemother. 1972 Feb;1(2):148–158. doi: 10.1128/aac.1.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ries K., Levison M. E., Kaye D. Clinical and in vitro evaluation of cefazolin, a new cephalosporin antibiotic. Antimicrob Agents Chemother. 1973 Feb;3(2):168–174. doi: 10.1128/aac.3.2.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ries K., Levison M. E., Kaye D. Transtracheal aspiration in pulmonary infection. Arch Intern Med. 1974 Mar;133(3):453–458. [PubMed] [Google Scholar]
  18. Sutter V. L., Kwok Y. Y., Finegold S. M. Standardized antimicrobial disc susceptibility testing of anaerobic bacteria. I. Susceptibility of Bacteroides fragilis to tetracycline. Appl Microbiol. 1972 Feb;23(2):268–275. doi: 10.1128/am.23.2.268-275.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. TYNES B. S., FROMMEYER W. B., Jr Bacteroides septicemia. Cultural, clinical, and therapeutic features in a series of twenty-five patients. Ann Intern Med. 1962 Jan;56:12–26. doi: 10.7326/0003-4819-56-1-12. [DOI] [PubMed] [Google Scholar]

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