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. 1974 Mar;5(3):289–293. doi: 10.1128/aac.5.3.289

Efficacy of Trimethoprim and Sulfamethoxazole in the Prevention and Treatment of Pneumocystis carinii Pneumonitis

Walter T Hughes 1, Paul C McNabb 1, Thomas D Makres 1, Sandor Feldman 1
PMCID: PMC428962  PMID: 4365115

Abstract

A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats. Although all of 15 untreated rats died with P. carinii pneumonitis, none of 15 given trimethoprim-sulfamethoxazole prophylactically acquired the infection. After P. carinii pneumonitis was established, 9 of 14 rats recovered after treatment with trimethoprim-sulfamethoxazole compared with only 2 of 14 treated with pentamidine isethionate. Rifampin and clindamycin, separately or in combination with pentamidine, were ineffective in the prevention and treatment of P. carinii infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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