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. 1974 Mar;5(3):323–329. doi: 10.1128/aac.5.3.323

Methods for Evaluating Topical Antibacterial Agents on Human Skin

R R Marples a,1, A M Kligman a
PMCID: PMC428968  PMID: 4840440

Abstract

Three procedures were presented for appraising the ability of antibacterial chemicals and formulations to suppress the growth of microorganisms on human skin. In each of these, the microflora was quantified after the skin had been occlusively covered for a day or more, a circumstance which, in the absence of a deterrent, led to an explosive overgrowth by resident organisms. The data obtained related to (i) the capacity to prevent expansion of the normal microflora, (ii) the suppression of an already expanded flora, and (iii) the persistence of antibacterial effect 3 days after the last application.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blank H., Taplin D., Zaias N. Cutaneous Trichophyton mentagrophytes infections in Vietnam. Arch Dermatol. 1969 Feb;99(2):135–144. [PubMed] [Google Scholar]
  2. Davis C. M., Fulghum D. D., Taplin D. The value of neomycin in a neomycin-steroid cream. JAMA. 1968 Jan 22;203(4):298–300. [PubMed] [Google Scholar]
  3. Dudding B. A., Burnett J. W., Chapman S. S., Wannamaker L. W. The role of normal skin in the spread of streptococcal pyoderma. J Hyg (Lond) 1970 Mar;68(1):19–28. doi: 10.1017/s0022172400028461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hojyo-Tomoka M. T., Marples R. R., Kligman A. M. Pseudomonas infection in superhydrated skin. Arch Dermatol. 1973 May;107(5):723–727. [PubMed] [Google Scholar]
  5. KING T. C., PRICE P. B. An evaluation of iodophors as skin antiseptics. Surg Gynecol Obstet. 1963 Mar;116:361–365. [PubMed] [Google Scholar]
  6. Leyden J. J., Marples R. R. Ecologic principles and antibiotic therapy in chronic dermatoses. Arch Dermatol. 1973 Feb;107(2):208–211. [PubMed] [Google Scholar]
  7. Leyden J. J., Marples R. R. Superinfection induced by antibiotics in familial benign chronic pemphigus. Acta Derm Venereol. 1973;53(1):61–64. [PubMed] [Google Scholar]
  8. Marples R. R., Kligman A. M. Limitations of paired comparisons of topical drugs. Br J Dermatol. 1973 Jan;88(1):61–67. doi: 10.1111/j.1365-2133.1973.tb06673.x. [DOI] [PubMed] [Google Scholar]
  9. Rebora A., Marples R. R., Kligman A. M. Experimental infection with Candida albicans. Arch Dermatol. 1973 Jul;108(1):69–73. [PubMed] [Google Scholar]
  10. Williamson P., Kligman A. M. A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol. 1965 Dec;45(6):498–503. doi: 10.1038/jid.1965.164. [DOI] [PubMed] [Google Scholar]

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