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. 1974 Apr;5(4):426–430. doi: 10.1128/aac.5.4.426

Effect of Certain Polypeptides on the Biological Activities of Measles Virus

Erling Norrby 1,2, Hans Sievertsson 1,2
PMCID: PMC428987  PMID: 15825400

Abstract

The effect of a selected tripeptide, Z-d-Phe-Phe-Arg(NO2) (SV-4814) on the kinetics of lysis of green monkey erythrocytes by measles virus hemolysin suggested conditions of competitive inhibition. SV-4814 prevented not only hemoglobin release, but also the preceding leakage of K+ through the cell membrane. The capacity of 12 different dipeptides, 6 tripeptides, including SV-4814, and 4 tetrapeptides to inhibit measles virus-specific hemolysis and infectivity was analyzed. Tri- and tetrapeptides were more active than dipeptides. The presence of aromatic amino acids and a free carboxyl terminal appeared to be a prerequisite for inhibitory activity. Two compounds, one tripeptide (Z-Phe-d-Phe-d-Tyr) and one tetrapeptide [Z-d-Phe-Arg(NO2)-d-Met], carried an inhibitory activity, which was about two times higher than that of SV-4814.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbanti-Brodano G., Oyanagi S., Katz M., Koprowski H. Presence of 2 different viral agents in brain cells of patients with subacute sclerosing panencephalitis. Proc Soc Exp Biol Med. 1970 May;134(1):230–236. doi: 10.3181/00379727-134-34765. [DOI] [PubMed] [Google Scholar]
  2. Falke D., Kahl G. F. The inhibitory effect of compound 48-80 on the formation of giant cells induced by herpesvirus hominis. J Gen Virol. 1971 Mar;10(3):273–277. doi: 10.1099/0022-1317-10-3-273. [DOI] [PubMed] [Google Scholar]
  3. KLEMPERER H. G. Hemolysis and the release of potassium from cells by Newcastle disease virus (NDV). Virology. 1960 Dec;12:540–552. doi: 10.1016/0042-6822(60)90177-x. [DOI] [PubMed] [Google Scholar]
  4. König W., Geiger R. Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexycarbodiimid unter Zusatz von 1-Hydroxy-benzotriazolen. Chem Ber. 1970;103(3):788–798. doi: 10.1002/cber.19701030319. [DOI] [PubMed] [Google Scholar]
  5. Miller F. A., Dixon G. J., Arnett G., Dice J. R., Rightsel W. A., Schabel F. M., Jr, McLean I. W., Jr Antiviral activity of carbobenzosy di- and tripeptides on measles virus. Appl Microbiol. 1968 Oct;16(10):1489–1496. doi: 10.1128/am.16.10.1489-1496.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. NEURATH A. R. INTERACTION OF SENDAI VIRUS WITH RED BLOOD CELLS.I. ADSORPTION, ELUTION AND THEIR RELATIONSHIP TO HAEMOLYSIS. Acta Virol. 1965 Jan;9:34–46. [PubMed] [Google Scholar]
  7. Neurath A. R., Vernon S. K., Hartzell R. W., Rubin B. A. Virocidal cleavage of disulphide bonds within structural proteins of Sendai virus. J Gen Virol. 1973 Apr;19(1):9–20. doi: 10.1099/0022-1317-19-1-9. [DOI] [PubMed] [Google Scholar]
  8. Nicolaides E., DeWald H., Lipnik M., Westland R., Posler J. Potential antiviral agents. Carbobenzoxy di- and tripeptides active against measles and herpes viruses. J Med Chem. 1968 Jan;11(1):74–79. doi: 10.1021/jm00307a016. [DOI] [PubMed] [Google Scholar]
  9. Norrby E., Gollmar Y. Appearance and persistence of antibodies against different virus components after regular measles infections. Infect Immun. 1972 Sep;6(3):240–247. doi: 10.1128/iai.6.3.240-247.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Norrby E. The effect of a carbobenzoxy tripeptide on the biological activities of measles virus. Virology. 1971 Jun;44(3):599–608. doi: 10.1016/0042-6822(71)90374-6. [DOI] [PubMed] [Google Scholar]
  11. ODDO F. G., FLACCOMIO R., SINATRA A. "Giant-cell" and "strand-forming" cytopathic effect of measles virus lines conditioned by serial propagation with diluted or concentrated inoculum. Virology. 1961 Apr;13:550–553. doi: 10.1016/0042-6822(61)90288-4. [DOI] [PubMed] [Google Scholar]
  12. Sievertsson H., Castensson S., Bowers C. Y., Friesen H. G., Folkers K. Snythesis of analogs of the thyrotropin releasing hormone (TRH) and bioassays for TRH- and TRH-inhibiting activities. Acta Pharm Suec. 1973 Sep;10(4):297–308. [PubMed] [Google Scholar]
  13. Singer S. J., Nicolson G. L. The fluid mosaic model of the structure of cell membranes. Science. 1972 Feb 18;175(4023):720–731. doi: 10.1126/science.175.4023.720. [DOI] [PubMed] [Google Scholar]

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