Abstract
The new aminoglycoside antibiotic, amikacin (formerly called BB-K8), was used to treat 12 episodes of urinary tract infection caused by hospital-acquired Proteus rettgeri strains. These bacteria were resistant in vitro to kanamycin and gentamicin, and infection persisted in most of the patients in spite of therapy with one of these agents. In all cases, the urinary tract infection was controlled or eradicated by therapy, although relapse or reinfection was frequently encountered in these patients with complicated urological problems. No toxicities attributable to the drug were encountered in the small group of patients.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
- Bodey G. P., Stewart D. In vitro studies of BB-K8, a new aminoglycoside antibiotic. Antimicrob Agents Chemother. 1973 Aug;4(2):186–192. doi: 10.1128/aac.4.2.186. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cabana B. E., Taggart J. G. Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans. Antimicrob Agents Chemother. 1973 Apr;3(4):478–483. doi: 10.1128/aac.3.4.478. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kawaguchi H., Naito T., Nakagawa S., Fujisawa K. I. BB-K 8, a new semisynthetic aminoglycoside antibiotic. J Antibiot (Tokyo) 1972 Dec;25(12):695–708. doi: 10.7164/antibiotics.25.695. [DOI] [PubMed] [Google Scholar]
- Naito T., Nakagawa S., Abe Y., Toda S., Fujisawa K. Aminoglycoside antibiotics. II. Configurational and positional isomers of BB-K8. J Antibiot (Tokyo) 1973 May;26(5):297–301. [PubMed] [Google Scholar]
- Price K. E., Chisholm D. R., Misiek M., Leitner F., Tsai Y. H. Microbiological evaluation of BB-K 8, a new semisynthetic aminoglycoside. J Antibiot (Tokyo) 1972 Dec;25(12):709–731. doi: 10.7164/antibiotics.25.709. [DOI] [PubMed] [Google Scholar]
- Reiffenstein J. C., Holmes S. W., Hottendorf G. H., Bierwagen M. E. Ototoxicity studies with BB-K8, a new semisynthetic aminoglycoside antibiotic. J Antibiot (Tokyo) 1973 Feb;26(2):94–100. doi: 10.7164/antibiotics.26.94. [DOI] [PubMed] [Google Scholar]
- Ries K., Levison M. E., Kaye D. In vitro evaluation of a new aminoglycoside derivative of kanamycin, a comparison with tobramycin and gentamycin. Antimicrob Agents Chemother. 1973 Apr;3(4):532–533. doi: 10.1128/aac.3.4.532. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yu P. K., Washington J. A., 2nd Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin. Antimicrob Agents Chemother. 1973 Aug;4(2):133–139. doi: 10.1128/aac.4.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]