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. 1974 May;5(5):444–446. doi: 10.1128/aac.5.5.444

Comparison of the Distribution of Tobramycin and Gentamicin in Body Fluids of Dogs

James J Szwed 1, Friedrich C Luft 1, H R Black 1, Roger A Elliott 1, Stuart A Kleit 1
PMCID: PMC428991  PMID: 4462459

Abstract

Tobramycin serum, thoracic lymph, renal lymph, and urine concentrations were measured in mongrel dogs after intravenously administered 5, 10, and 20 mg/kg doses. These were compared with intravenous gentamicin delivered at 5 and 20 mg/kg. Both drugs achieved similar concentrations in serum and thoracic lymph. At 20 mg/kg, tobramycin showed consistently higher renal lymph and urine concentrations than gentamicin. At 5 mg of tobramycin per kg, renal lymph and urine concentrations were higher than with gentamicin only within the 1st h after administration. Thereafter the difference was no longer significant. These data suggest that on the basis of distribution in the body fluids of dogs, tobramycin is a reasonable alternative to gentamicin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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