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. 1974 May;5(5):485–491. doi: 10.1128/aac.5.5.485

Mechanism of the Antiviral Action of 3-Methyleneoxindole

V Tuli 1
PMCID: PMC429000  PMID: 4376909

Abstract

The biochemical basis underlying the antiviral action of 3-methyleneoxindole (MO), a plant metabolite, was examined in HeLa cells infected with poliovirus. In the presence of antiviral concentrations of MO, poliovirus-specific ribonucleic acid (RNA) synthesis can proceed normally, and the RNA synthesized under such conditions is infectious. It is suggested that the ability of MO to bind to ribosomes of HeLa cells may underlie the antiviral affect. Data are presented which indicate that poliovirus messenger RNA cannot attach to those ribosomes which already are bound to MO. Consequently, virus-specific polysomes cannot be recovered from infected cells treated with antiviral concentrations of MO. In contrast, antiviral concentrations of MO do not prevent the formation of polysomes in uninfected HeLa cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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