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. 1994 Jan 4;91(1):138–142. doi: 10.1073/pnas.91.1.138

Sialokinin I and II: vasodilatory tachykinins from the yellow fever mosquito Aedes aegypti.

D E Champagne 1, J M Ribeiro 1
PMCID: PMC42901  PMID: 8278354

Abstract

The saliva of the mosquito Aedes aegypti has previously been reported to contain a 1400-Da peptide with pharmacological properties typical of a tachykinin. In the present study this vasodilator has been purified to homogeneity and found to consist of two peptides: sialokinin I, with the sequence Asn-Thr-Gly-Asp-Lys-Phe-Tyr-Gly-Leu-Met-NH2, and sialokinin II, identical to sialokinin I except for an Asp in position 1. These peptides are present in amounts of 0.62 and 0.16 pmol (711 and 178 ng), respectively, per salivary gland pair. When assayed on the guinea pig ileum, both peptides are as active as the mammalian tachykinin substance P, with K0.5 values of 5.07, 6.58, and 4.94 nM for sialokinin I, sialokinin II, and substance P, respectively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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