Abstract
Studies were conducted in 30 patients with neoplastic diseases. Twelve patients received sisomicin intramuscularly at doses of 20 mg/m2 and 40 mg/m2. The mean peak serum concentration occurred at 1 h and was 2.5 μg/ml and 4.0 μg/ml, respectively. Ten patients received intravenous sisomicin at doses of 30 mg/m2 during 30-min infusion. Mean peak serum level determined at 30 min was 5.1 μg/ml. The levels gradually decreased and at 6 h was 0.6 μg/ml. The serum half-life was 160 min. Serum levels determined in eight patients who received sisomicin by continuous infusion at doses of 30 mg/m2 every 6 h were greater than 1.4 μg/ml during the 6-h period. The urinary excretion of sisomicin during the 6-h period after intramuscular administration of 20 mg/m2 and 40 mg/m2 was 49 and 61%, respectively. The pharmacology of sisomicin is similar to gentamicin.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BULGER R. J., SIDELL S., KIRBY W. M. LABORATORY AND CLINICAL STUDIES OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC. Ann Intern Med. 1963 Nov;59:593–604. doi: 10.7326/0003-4819-59-5-593. [DOI] [PubMed] [Google Scholar]
- Waitz J. A., Moss E. L., Jr, Oden E. M., Weinstein M. J. Antibiotic 6640. 3. Biological studies with antibiotic 6640, a new broad-spectrum aminoglycoside antibiotic. J Antibiot (Tokyo) 1970 Nov;23(11):559–565. [PubMed] [Google Scholar]
- Weinstein M. J., Marquez J. A., Testa R. T., Wagman G. H., Oden E. M., Waitz J. A. Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic. J Antibiot (Tokyo) 1970 Nov;23(11):551–554. doi: 10.7164/antibiotics.23.551. [DOI] [PubMed] [Google Scholar]