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. 1975 Jan;7(1):55–57. doi: 10.1128/aac.7.1.55

Comparative Effect of Tetracycline and Doxycycline on the Occurrence of Resistant Escherichia coli in the Fecal Flora

John G Bartlett *, Larry A Bustetter , Sherwood L Gorbach , Andrew B Onderdonk
PMCID: PMC429072  PMID: 1094945

Abstract

Antibiotic-induced changes in the fecal microflora after oral administration of tetracycline hydrochloride and doxycycline for 8 to 10 days were compared. A significant difference was noted in the concentrations of Escherichia coli resistant to tetracyclines. With tetracycline hydrochloride, there was a mean increase of approximately 104 resistant strains per g compared to only 101/g for doxycycline. This difference is ascribed to reduced intestinal concentrations of bioactive drug with recommended oral dosage for doxycycline.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DEARING W. H., HEILMAN F. R. The effect of aureomycin on the bacterial flora of the intestinal tract of man; a contribution to preoperative preparation. Proc Staff Meet Mayo Clin. 1950 Feb 15;25(4):87–102. [PubMed] [Google Scholar]
  2. DEARING W. H., NEEDHAM G. M. The effect of terramycin on the intestinal bacterial flora of patients being prepared for intestinal surgery. Proc Staff Meet Mayo Clin. 1951 Jan 31;26(3):49–52. [PubMed] [Google Scholar]
  3. Fabre J., Milek E., Kalfopoulos P., Mérier G. La cinétique des tétracyclines chez l'homme. I. Absorption digestive et concentrations sériques. Schweiz Med Wochenschr. 1971 May 1;101(17):593–598. [PubMed] [Google Scholar]
  4. Hinton N. A. The effect of oral tetracycline HCl and doxycycline on the intestinal flora. Curr Ther Res Clin Exp. 1970 Jun;12(6):341–352. [PubMed] [Google Scholar]
  5. Hirsh D. C., Burton G. C., Blenden D. C. Effect of oral tetracycline on the occurrence of tetracycline-resistant strains of Escherichia coli in the intestinal tract of humans. Antimicrob Agents Chemother. 1973 Jul;4(1):69–71. doi: 10.1128/aac.4.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KUNIN C. M., DORNBUSH A. C., FINLAND M. Distribution and excretion of four tetracycline analogues in normal young men. J Clin Invest. 1959 Nov;38:1950–1963. doi: 10.1172/JCI103974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Schach von Wittenau M., Twomey T. M. The disposition of doxycyline by man and dog. Chemotherapy. 1971;16(4):217–228. doi: 10.1159/000220730. [DOI] [PubMed] [Google Scholar]

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