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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1975 Feb;7(2):128–132. doi: 10.1128/aac.7.2.128

Susceptibility of Anaerobes to Cefoxitin and Other Cephalosporins

Francis P Tally *, Nilda V Jacobus , John G Bartlett , Sherwood L Gorbach
PMCID: PMC429091  PMID: 1137364

Abstract

The in vitro susceptibility of 155 strains of anaerobic bacteria to five cephalosporin antibiotics was tested. Cefoxitin was the most active against 33 isolates of Bacteroides fragilis; 82% of the strains were sensitive at 16 μg/ml. At 64 μg/ml cefazolin and cephaloridine were also generally effective. Cephalothin and cephalexin were relatively inactive versus B. fragilis. Cefoxitin, cephaloridine, cefazolin, and cephalothin showed comparable activity against 122 strains of anaerobes other than B. fragilis. More than 90% of the strains were sensitive to each of these antimicrobials at 16 μg/ml. Cephalexin was the least effective cephalosporin against all species tested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. D., Sykes R. B. Characterisation of a -lactamase obtained from a strain of Bacteroides fragilis resistant to -lactam antibiotics. J Med Microbiol. 1973 May;6(2):201–206. doi: 10.1099/00222615-6-2-201. [DOI] [PubMed] [Google Scholar]
  2. Cahn M. M., Levy E. J., Actor P., Pauls J. F. Comparative serum levels and urinary recovery of cefazolin, cephaloridine, and cephalothin in man. J Clin Pharmacol. 1974 Jan;14(1):61–66. doi: 10.1002/j.1552-4604.1974.tb02289.x. [DOI] [PubMed] [Google Scholar]
  3. Daoust D. R., Onishi H. R., Wallick H., Hendlin D., Stapley E. O. Cephamycins, a new family of beta-lactam antibiotics: antibacterial activity and resistance to beta-lactamase degradation. Antimicrob Agents Chemother. 1973 Feb;3(2):254–261. doi: 10.1128/aac.3.2.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Del Bene V. E., Farrar W. E., Jr Cephalosporinase activity in Bacteroides fragilis. Antimicrob Agents Chemother. 1973 Mar;3(3):369–372. doi: 10.1128/aac.3.3.369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  6. Gorbach S. L., Bartlett J. G. Anaerobic infections. 1. N Engl J Med. 1974 May 23;290(21):1177–1184. doi: 10.1056/NEJM197405232902106. [DOI] [PubMed] [Google Scholar]
  7. Griffith R. S., Black H. R. Blood, urine and tissue concentrations of the cephalosporin antibiotics in normal subjects. Postgrad Med J. 1971 Feb;47(Suppl):32–40. [PubMed] [Google Scholar]
  8. Kislak J. W. The susceptibility of Bacteroides fragilis to 24 antibiotics. J Infect Dis. 1972 Mar;125(3):295–299. doi: 10.1093/infdis/125.3.295. [DOI] [PubMed] [Google Scholar]
  9. Kosmidis J., Hamilton-Miller J. M., Gilchrist J. N., Kerry D. W., Brumfitt W. Cefoxitin, a new semi-synthetic cephamycin: an in-vitro and in-vivo comparison with cephalothin. Br Med J. 1973 Dec 15;4(5893):653–655. doi: 10.1136/bmj.4.5893.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Martin W. J., Gardner M., Washington J. A., 2nd In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens. Antimicrob Agents Chemother. 1972 Feb;1(2):148–158. doi: 10.1128/aac.1.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Onishi H. R., Daoust D. R., Zimmerman S. B., Hendlin D., Stapley E. O. Cefoxitin, a semisynthetic cephamycin antibiotic: resistance to beta-lactamase inactivation. Antimicrob Agents Chemother. 1974 Jan;5(1):38–48. doi: 10.1128/aac.5.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Thadepalli H., Gorbach S. L., Broido P. W., Norsen J., Nyhus L. Abdominal trauma, anaerobes, and antibiotics. Surg Gynecol Obstet. 1973 Aug;137(2):270–276. [PubMed] [Google Scholar]
  13. Wallick H., Hendlin D. Cefoxitin, a semisynthetic cephamycin antibiotic: susceptibility studies. Antimicrob Agents Chemother. 1974 Jan;5(1):25–32. doi: 10.1128/aac.5.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]

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