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. 1975 Feb;7(2):139–145. doi: 10.1128/aac.7.2.139

Production and Mode of Action of Lactocin 27: Bacteriocin from a Homofermentative Lactobacillus

G C Upreti 1, R D Hinsdill 1
PMCID: PMC429093  PMID: 1137365

Abstract

Lactobacillus helveticus strain LP27 produced a bacteriocin, lactocin 27, in dialyzable and nondialyzable forms. No evidence was obtained to indicate that lactocin 27 was under the control of extrachromosomal plasmids. Lactocin 27 had a bacteriostatic effect on the indicator, Lactobacillus helveticus strain LS18. It inhibited primarily protein synthesis without affecting deoxyribonucleic acid and ribonucleic acid synthesis or adenosine 5′-triphosphate levels. Treatment of susceptible cells with the lactocin did not cause leakage of ultraviolet-absorbing material, but caused the efflux of potassium ions and the influx of sodium ions. It adsorbed non-specifically to various bacterial species irrespective of their susceptibility to lactocin 27. However, the presence of specific receptors has not been ruled out.

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Selected References

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