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. 1975 Mar;7(3):289–293. doi: 10.1128/aac.7.3.289

Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice1

Richard J Klein a, Alvin E Friedman-Kien a
PMCID: PMC429126  PMID: 166611

Abstract

Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-β-d-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-β-d-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUTHALA D. A. CELL CULTURE STUDIES ON ANTIVIRAL AGENTS. I. ACTION OF CYTOSINE ARABINOSIDE AND SOME COMPARISONS WITH 5-IODO-2-DEOXYURIDINE. Proc Soc Exp Biol Med. 1964 Jan;115:69–77. doi: 10.3181/00379727-115-28834. [DOI] [PubMed] [Google Scholar]
  2. Klein R. J., Friedman-Kien A. E., Brady E. Herpes simplex virus skin infection in hairless mice: treatment with antiviral compounds. Antimicrob Agents Chemother. 1974 Mar;5(3):318–322. doi: 10.1128/aac.5.3.318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lieberman M., Schafer T. W., Came P. E. Chemotherapy of cutaneous herpesvirus infection of hairless mice. J Invest Dermatol. 1973 Apr;60(4):203–206. doi: 10.1111/1523-1747.ep12724476. [DOI] [PubMed] [Google Scholar]
  4. Nesburn A. B., Robinson C., Dickinson R. Adenine arabinoside effect on experimental idoxuridine-resistant herpes simplex infection. Invest Ophthalmol. 1974 Apr;13(4):302–304. [PubMed] [Google Scholar]
  5. Pavan-Langston D., Dohlman C. H. A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis. Am J Ophthalmol. 1972 Jul;74(1):81–88. doi: 10.1016/0002-9394(72)91130-0. [DOI] [PubMed] [Google Scholar]
  6. Renis H. E., Buthala D. A. Development of resistance to antiviral drugs. Ann N Y Acad Sci. 1965 Jul 30;130(1):343–354. doi: 10.1111/j.1749-6632.1965.tb12568.x. [DOI] [PubMed] [Google Scholar]
  7. Schabel F. M., Jr The antiviral activity of 9-beta-D-arabinofuranosyladenine (ARA-A). Chemotherapy. 1968;13(6):321–338. doi: 10.1159/000220567. [DOI] [PubMed] [Google Scholar]
  8. Shipkowitz N. L., Bower R. R., Appell R. N., Nordeen C. W., Overby L. R., Roderick W. R., Schleicher J. B., Von Esch A. M. Suppression of herpes simplex virus infection by phosphonoacetic acid. Appl Microbiol. 1973 Sep;26(3):264–267. doi: 10.1128/am.26.3.264-267.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sloan B. J., Miller F. A., McLean I. W., Jr Treatment of herpes simplex virus types 1 and 2 encephalitis in mice with 9-beta-D-arabinofuranosyladenine. Antimicrob Agents Chemother. 1973 Jan;3(1):74–80. doi: 10.1128/aac.3.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. White D. O., Shew M. A., Howsam K. G., Robertson I. F. Herpes simplex virus infection of the cornea. Med J Aust. 1968 Jul 13;2(2):59–63. doi: 10.5694/j.1326-5377.1968.tb29290.x. [DOI] [PubMed] [Google Scholar]

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