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. 1975 Mar;7(3):328–332. doi: 10.1128/aac.7.3.328

Gentamicin and Gentamicin C1 in the Treatment of Complicated Urinary Tract Infections: Comparative Study of Efficacy, Tolerance, and Pharmacokinetics

Aage Mosegaard *, Peter G Welling *, Paul O Madsen *
PMCID: PMC429134  PMID: 1137386

Abstract

The clinical efficacy, patient tolerance, and pharmacokinetics of gentamicin and the single component gentamicin C1 were studied after single and multiple doses in elderly male patients. Patient tolerance was extremely good at the dose levels used. There was some evidence of renal function impairment due to repeated intramuscular doses of gentamicin, but not gentamicin C1. The antibiotics were equally effective against the organisms present in the urine of these patients. The pharmacokinetics of the two antibiotic forms were similar, although gentamicin C1 appeared to have a larger distribution space.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Meyers B. R., Hirschman S. Z. Pharmacologic studies on tobramycin and comparison with gentamicin. J Clin Pharmacol New Drugs. 1972 Aug-Sep;12(8):321–324. doi: 10.1002/j.1552-4604.1972.tb00174.x. [DOI] [PubMed] [Google Scholar]
  3. Regamey C., Gordon R. C., Kirby W. M. Comparative pharmacokinetics of tobramycin and gentamicin. Clin Pharmacol Ther. 1973 May-Jun;14(3):396–403. doi: 10.1002/cpt1973143396. [DOI] [PubMed] [Google Scholar]
  4. Sigman E. M., Elwood C. M., Knox F. The measurement of glomerular filtration rate in man with sodium iothalamate 131-I (Conray). J Nucl Med. 1966 Jan;7(1):60–68. [PubMed] [Google Scholar]
  5. WAGONER R. D., TAUXE W. N., MAHER F. T., HUNT J. C. MEASUREMENT OF EFFECTIVE RENAL PLASMA FLOW WITH SODIUM IODOHIPPURATE I-131. JAMA. 1964 Mar 14;187:811–813. doi: 10.1001/jama.1964.03060240019004. [DOI] [PubMed] [Google Scholar]
  6. Wagner J. G., Northam J. I. Estimation of volume of distribution and half-life of a compound after rapid intravenous injection. J Pharm Sci. 1967 Apr;56(4):529–531. doi: 10.1002/jps.2600560424. [DOI] [PubMed] [Google Scholar]
  7. Wilfert J. N., Burke J. P., Bloomer H. A., Smith C. B. Renal insufficiency associated with gentamicin therapy. J Infect Dis. 1971 Dec;124 (Suppl):S148–S155. doi: 10.1093/infdis/124.supplement_1.s148. [DOI] [PubMed] [Google Scholar]
  8. Wilson T. W., Mahon W. A., Inaba T., Johnson G. E., Kadar D. Elimination of tritiated gentamicin in normal human subjects and in patients with severely impaired renal function. Clin Pharmacol Ther. 1973 Sep-Oct;14(5):815–822. doi: 10.1002/cpt1973145815. [DOI] [PubMed] [Google Scholar]

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