Abstract
The in vitro inactivation of gentamicin by carbenicillin and a new semisynthetic penicillin, ticarcillin (BRL 2288), has been demonstrated. Gentamicin half-lives have been studied in eight patients with end-stage renal failure, and a 25 to 74% reduction in half-life has resulted from the concomitant administration of therapeutic doses of carbenicillin and ticarcillin.
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Selected References
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- Andriole V. T. Synergy of carbenicillin and gentamicin in experimental infection with Pseudomonas. J Infect Dis. 1971 Dec;124 (Suppl):S46–S55. doi: 10.1093/infdis/124.supplement_1.s46. [DOI] [PubMed] [Google Scholar]
- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brumfitt W., Percival A., Leigh D. A. Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea. Lancet. 1967 Jun 17;1(7503):1289–1293. doi: 10.1016/s0140-6736(67)91590-5. [DOI] [PubMed] [Google Scholar]
- Lynn B. Administration of carbenicillin and ticarcillin--pharmaceutical aspects. Eur J Cancer. 1973 Jun;9(6):425–433. doi: 10.1016/0014-2964(73)90107-2. [DOI] [PubMed] [Google Scholar]
- McLaughlin J. E., Reeves D. S. Clinical and laboratory evidence for inactivation of gentamicin by carbenicillin. Lancet. 1971 Feb 6;1(7693):261–264. doi: 10.1016/s0140-6736(71)91001-4. [DOI] [PubMed] [Google Scholar]
- Riff L. J., Jackson G. G. Laboratory and clinical conditions for gentamicin inactivation by carbenicillin. Arch Intern Med. 1972 Dec;130(6):887–891. [PubMed] [Google Scholar]
- Smith C. B., Dans P. E., Wilfert J. N., Finland M. Use of gentamicin in combinations with other antibiotics. J Infect Dis. 1969 Apr-May;119(4):370–377. doi: 10.1093/infdis/119.4-5.370. [DOI] [PubMed] [Google Scholar]
- Sonne M., Jawetz E. Combined action of carbenicillin and gentamicin on Pseudomonas aeruginosa in vitro. Appl Microbiol. 1969 Jun;17(6):893–896. doi: 10.1128/am.17.6.893-896.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Winters R. E., Chow A. W., Hecht R. H., Hewitt W. L. Combined use of gentamicin and carbenicillin. Ann Intern Med. 1971 Dec;75(6):925–927. doi: 10.7326/0003-4819-75-6-925. [DOI] [PubMed] [Google Scholar]