Abstract
Specific-pathogen-free CD-1 mice were treated orally with the drug tilorone (2,7-bis[2-diethylaminoethoxy]fluoren-9-one hydrochloride) at dosages of 10 or 100 mg per kg of body weight. Drug was given 24 h before challenge and then every other day for up to 15 days. Growth of sublethal doses of Listeria monocytogenes, Mycobacterium bovis (BCG Montreal), M. tuberculosis H37Rv, and Salmonella enteritidis in the livers and spleens of intravenously challenged mice was significantly increased compared with that in control animals receiving distilled water orally. Tilorone given every other day at a dosage of 10 mg/kg reduced (but did not completely ablate) the tuberculin response to the mycobacterial infections. Both tuberculin hypersensitivity and anti-mycobacterial resistance returned to normal values within days of stopping the drug treatment. Tilorone treatment at the 100-mg/kg dose level increased the growth of S. enteritidis in both intravenously and intragastrically challenged mice; this effect seemed to be due to the reduced ability of the host to express the normal granulomatous response to the microbial infection within the liver and spleen.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Collins F. M., Carter P. B. Comparative immunogenicity of heat-killed and living oral Salmonella vaccines. Infect Immun. 1972 Oct;6(4):451–458. doi: 10.1128/iai.6.4.451-458.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Collins F. M. Effect of oral niridazole treatment on some bacterial infections in mice. Antimicrob Agents Chemother. 1975 Apr;7(4):453–456. doi: 10.1128/aac.7.4.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Collins F. M., Mackaness G. B. The relationship of delayed hypersensitivity to acquired antituberculous immunity. I. Tuberculin sensitivity and resistance to reinfection in BCG-vaccinated mice. Cell Immunol. 1970 Sep;1(3):253–265. doi: 10.1016/0008-8749(70)90047-x. [DOI] [PubMed] [Google Scholar]
- Collins F. M. Mechanisms in antimicrobial immunity. J Reticuloendothel Soc. 1971 Jul;10(1):58–99. [PubMed] [Google Scholar]
- De Clercq E., Merigan T. C. Bis-DEAE-fluorenone: mechanism of antiviral protection and stimulation of interferon production in the mouse. J Infect Dis. 1971 Feb;123(2):190–199. doi: 10.1093/infdis/123.2.190. [DOI] [PubMed] [Google Scholar]
- Diamantstein T. Stimulation of humoral immune response by tilorone hydrochloride. Immunology. 1973 Apr;24(4):771–775. [PMC free article] [PubMed] [Google Scholar]
- FLAX M. H., WAKSMAN B. H. Delayed cutaneous reactions in the rat. J Immunol. 1962 Oct;89:496–504. [PubMed] [Google Scholar]
- Mackaness G. B., Blanden R. V., Collins F. M. Host-parasite relations in mouse typhoid. J Exp Med. 1966 Oct 1;124(4):573–583. doi: 10.1084/jem.124.4.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mackaness G. B. Resistance to intracellular infection. J Infect Dis. 1971 Apr;123(4):439–445. doi: 10.1093/infdis/123.4.439. [DOI] [PubMed] [Google Scholar]
- Megel H., Raychaudhuri A., Goldstein S., Kinsolving C. R., Shemano I., Michael J. G. Tilorone: its selective effects on humoral and cell-mediated immunity. Proc Soc Exp Biol Med. 1974 Feb;145(2):513–518. doi: 10.3181/00379727-145-37842. [DOI] [PubMed] [Google Scholar]