Abstract
Blood levels of cefazolin and cephalothin were determined in two separate crossover studies in 20 healthy male adults, each after intravenous and intramuscular administration. Pharmacokinetic parameters were calculated from the intravenous data based upon a two-compartment open model. The rate constants controlling the distribution between the central and peripheral compartments, the overall elimination rate constants, the apparent volumes of distribution, and the fraction of the dose in the central and peripheral compartments were determined. The bioavailability was calculated to be 100% for cefazolin and cephalothin.
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Selected References
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- Benner E. J. Cephalosporin antibiotics: therapeutic dimensions and future. Postgrad Med J. 1971 Feb;47(Suppl):135–142. [PubMed] [Google Scholar]
- Cahn M. M., Levy E. J., Actor P., Pauls J. F. Comparative serum levels and urinary recovery of cefazolin, cephaloridine, and cephalothin in man. J Clin Pharmacol. 1974 Jan;14(1):61–66. doi: 10.1002/j.1552-4604.1974.tb02289.x. [DOI] [PubMed] [Google Scholar]
- De Schepper P., Harvengt C., Vranckx C., Boon B., Lamy F. Pharmacologic study of cefazolin in volunteers. J Clin Pharmacol New Drugs. 1973 Feb-Mar;13(2):83–88. doi: 10.1002/j.1552-4604.1973.tb00257.x. [DOI] [PubMed] [Google Scholar]
- Gower P. E., Dash C. H., O'Callaghan C. H. Serum and blood concentration of sodium cephalexin in man given single intramuscular and intravenous injections. J Pharm Pharmacol. 1973 May;25(5):376–381. doi: 10.1111/j.2042-7158.1973.tb10031.x. [DOI] [PubMed] [Google Scholar]
- Kariyone K., Harada H., Kurita M., Takano T. Cefazolin, a new semisynthetic cephalosporin antibiotic. I. Synthesis and chemical properties of cefazolin. J Antibiot (Tokyo) 1970 Mar;23(3):131–136. doi: 10.7164/antibiotics.23.131. [DOI] [PubMed] [Google Scholar]
- Kirby W. M., De Maine J. B., Serrill W. S. Pharmacokinetics of the cephalosporins in healthy volunteers and uremic patients. Postgrad Med J. 1971 Feb;47(Suppl):41–46. [PubMed] [Google Scholar]
- Nicholas P., Meyers B. R., Hirschman S. Z. Pharmacology of cefazolin in human volunteers. J Clin Pharmacol. 1973 Aug-Sep;13(8):325–331. doi: 10.1002/j.1552-4604.1973.tb00219.x. [DOI] [PubMed] [Google Scholar]
- Nishida M., Matsubara T., Murakawa T., Mine Y., Yokota Y. Cefazolin, a new semisynthetic cephalosporin antibiotic. II. In vitro and in vivo antimicrobial activity. J Antibiot (Tokyo) 1970 Mar;23(3):137–148. doi: 10.7164/antibiotics.23.137. [DOI] [PubMed] [Google Scholar]
- Nishida M., Matsubara T., Murakawa T., Mine Y., Yokota Y., Goto S., Kuwahara S. Cefazolin, a new semisynthetic cephalosporin antibiotic. 3. Absorption, excretion and tissue distribution in parenteral administration. J Antibiot (Tokyo) 1970 Apr;23(4):184–194. [PubMed] [Google Scholar]
- Regamey C., Gordon R. C., Kirby W. M. Cefazolin vs cephalothin and cephaloridine. A comparison of their clinical pharmacology. Arch Intern Med. 1974 Mar;133(3):407–410. [PubMed] [Google Scholar]
- Riegelman S., Loo J. C., Rowland M. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J Pharm Sci. 1968 Jan;57(1):117–123. doi: 10.1002/jps.2600570123. [DOI] [PubMed] [Google Scholar]
- Wick W. E., Preston D. A. Biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics. Antimicrob Agents Chemother. 1972 Mar;1(3):221–234. doi: 10.1128/aac.1.3.221. [DOI] [PMC free article] [PubMed] [Google Scholar]