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. 1975 May;7(5):672–675. doi: 10.1128/aac.7.5.672

Treatment of Anaerobic Infections with Metronidazole

Francis P Tally *, Vera L Sutter , Sydney M Finegold
PMCID: PMC429201  PMID: 1096810

Abstract

The results of treatment of 10 patients with anaerobic infections with metronidazole are presented. Six patients were cured, three showed initial good response but circumstances required a change to another drug, and one patient did not respond. The unique spectrum of the drug, its pharmacology, and limitations are discussed. The results indicate that further clinical trials to determine the efficacy of metronidazole in the treatment of anerobic infections are indicated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartlett J. G., Finegold S. M. Anaerobic pleuropulmonary infections. Medicine (Baltimore) 1972 Nov;51(6):413–450. doi: 10.1097/00005792-197211000-00001. [DOI] [PubMed] [Google Scholar]
  2. Bartlett J. G., Sutter V. L., Finegold S. M. Treatment of anaerobic infections with lincomycin and clindamycin. N Engl J Med. 1972 Nov 16;287(20):1006–1010. doi: 10.1056/NEJM197211162872002. [DOI] [PubMed] [Google Scholar]
  3. COSAR C., JULOU L. Activité de l'(hydroxy-2'éthyl)-1 méthyl-2 nitro-5 imidazole (8.823 R. P.) vis-à-vis des infections expérimentales à Trichomonas vaginalis. Ann Inst Pasteur (Paris) 1959 Feb;96(2):238–241. [PubMed] [Google Scholar]
  4. Cohen L. E., McNeill C. J., Wells R. F. Clindamycin-associated colitis. JAMA. 1973 Mar 19;223(12):1379–1380. [PubMed] [Google Scholar]
  5. DAVIES A. H., MCFADZEAN J. A., SQUIRES S. TREATMENT OF VINCENT'S STOMATITIS WITH METRONIDAZOLE. Br Med J. 1964 May 2;1(5391):1149–1150. doi: 10.1136/bmj.1.5391.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Davies A. H. Metronidazole in human infections with syphilis. Br J Vener Dis. 1967 Sep;43(3):197–200. doi: 10.1136/sti.43.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gallant D. M., Bishop M. P., Camp E., Tisdale C. A six-month controlled evaluation of metronidazole (Flagyl) in chronic alcoholic patients. Curr Ther Res Clin Exp. 1968 Feb;10(2):82–87. [PubMed] [Google Scholar]
  8. KANE P. O., McFADZEAN J. A., SQUIRES S., KING A. J., NICOL C. S. Absorption and excretion of metronidazole. I. Serum concentration and urinary excretion after oral administration. Br J Vener Dis. 1961 Dec;37:273–275. doi: 10.1136/sti.37.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Martin W. J., Gardner M., Washington J. A., 2nd In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens. Antimicrob Agents Chemother. 1972 Feb;1(2):148–158. doi: 10.1128/aac.1.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mitre R. J., Rotheran E. B., Jr Anaerobic septicemia from thrombophlebitis of the internal jugular vein. Successful treatment with metronidazole. JAMA. 1974 Nov 25;230(8):1168–1169. [PubMed] [Google Scholar]
  11. Nastro L. J., Finegold S. M. Bactericidal activity of five antimicrobial agents against Bacteroides fragilis. J Infect Dis. 1972 Jul;126(1):104–107. doi: 10.1093/infdis/126.1.104. [DOI] [PubMed] [Google Scholar]
  12. Powell S. J. New developments in the therapy of amoebiasis. Gut. 1970 Nov;11(11):967–969. [PMC free article] [PubMed] [Google Scholar]
  13. Prince H. N., Grunberg E., Titsworth E., DeLorenzo W. F. Effects of l-(2-nitro-l-imidazolyl)-3-methoxy-2-propanol and 2-methyl-5-nitroimidazole-l-ethanol against anaerobic and aerobic bacteria and protozoa. Appl Microbiol. 1969 Nov;18(5):728–730. doi: 10.1128/am.18.5.728-730.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rothstein E., Clancy D. D. Toxicity of disulfiram combined with metronidazole. N Engl J Med. 1969 May 1;280(18):1006–1007. doi: 10.1056/NEJM196905012801807. [DOI] [PubMed] [Google Scholar]
  15. Tally F. P., Sutter V. L., Finegold S. M. Metronidazole versus anaerobes. In vitro data and initial clinical observations. Calif Med. 1972 Dec;117(6):22–26. [PMC free article] [PubMed] [Google Scholar]
  16. Tedesco F. J., Stanley R. J., Alpers D. H. Diagnostic features of clindamycin-associated pseudomembranous colitis. N Engl J Med. 1974 Apr 11;290(15):841–843. doi: 10.1056/NEJM197404112901508. [DOI] [PubMed] [Google Scholar]
  17. Wells R. F., Cohen L. E., McNeill C. J. Letter: Clindamycin and pseudomembranous colitis. Lancet. 1974 Jan 12;1(7846):66–66. doi: 10.1016/s0140-6736(74)93067-0. [DOI] [PubMed] [Google Scholar]
  18. Whelan J. P., Hale J. H. Bactericidal activity of metronidazole against Bacteroides fragilis. J Clin Pathol. 1973 Jun;26(6):393–395. doi: 10.1136/jcp.26.6.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wilkins T. D., Thiel T. Resistance of some species of Clostridium to clindamycin. Antimicrob Agents Chemother. 1973 Jan;3(1):136–137. doi: 10.1128/aac.3.1.136. [DOI] [PMC free article] [PubMed] [Google Scholar]

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