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. 1975 May;7(5):676–681. doi: 10.1128/aac.7.5.676

Genetic Analysis of Drug Resistance in Neisseria gonorrhoeae: Identification and Linkage Relationships of Loci Controlling Drug Resistance

Thomas W Maier 1, Leonard Zubrzycki 1, Marie B Coyle 1,1
PMCID: PMC429202  PMID: 807159

Abstract

The genetic basis of multiple drug resistance of Neisseria gonorrhoeae was investigated by the technique of transformation. Six different genetic loci were characterized by the type and amount of antibiotic resistance they controlled, and also by the degree of linkage to other resistance markers. A streptomycin resistance locus is linked to separate loci determining resistance to tetracycline, chloramphenicol, and erythromycin. A multiple resistance locus was identified. This genetic locus determines resistance to a variety of antibacterial agents. Lastly, a locus determining resistance to the penicillins was found which is unlinked to any other resistance locus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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