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. 1975 Jun;7(6):724–729. doi: 10.1128/aac.7.6.724

Comparative Chemotherapeutic Activity of Amphotericin B and Amphotericin B Methyl Ester

Daniel P Bonner 1, Ram P Tewari 1, Morris Solotorovsky 1, Witold Mechlinski 1, Carl P Schaffner 1
PMCID: PMC429217  PMID: 1155916

Abstract

The comparative efficacy of amphotericin B and amphotericin B methyl ester (AME) against experimental histoplasmosis, blastomycosis, cryptococcosis, and candidosis in mice was assessed by determining the effect of daily intraperitoneal therapy on 21-day survival and persistence of organisms in internal organs. AME, like amphotericin B, was effective against each of the experimental infections, but the efficacy was lower than the parent compound. For Histoplasma and Blastomyces infections the mean effective dose (ED50) of amphotericin B was 0.3 mg/kg, whereas the corresponding values for AME, respectively, were 2.4 and 2.8 mg/kg. For Cryptococcus infection the ED50 for amphotericin B was 0.2 mg/kg compared with 2.0 mg/kg for AME. The ED50 of amphotericin B for Candida infection was lower than 0.05 mg/kg and the value of AME was between 0.5 to 0.05 mg/kg. The colony counts from internal organs of the surviving animals after the therapeutic regimens were compatible with the data on survival.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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