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. 1975 Jun;7(6):736–741. doi: 10.1128/aac.7.6.736

Effects of Cytochalasin B on the Intracellular Bactericidal Activity of Human Neutrophils

Kenji Okuda 1
PMCID: PMC429219  PMID: 1155917

Abstract

Cytochalasin B (CB) is known to have some inhibitory effects on cytokinesis, single-cell movement, bacterial uptake by phagocytes, and many other processes. The effects of CB on intraleukocytic bactericidal activities in human leukocytes were studied, and the results were summarized as follows. (i) CB inhibited the early stage of the intracellular bactericidal activity of human leukocytes against Streptococcus pyogenes D58 (group A). The effect was rapidly eliminated by rinsing the CB solution. (ii) In the late stage of the intracellular bactericidal process, however, CB possessed no effect against S. pyogenes D58 (group A) and Staphylococcus aureus 209P. (iii) CB also inhibited the translocation of myeloperoxidase granules to the phagosomes of human neutrophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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