Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1975 Jun;7(6):845–849. doi: 10.1128/aac.7.6.845

Mechanism of Chloramphenicol-Cephaloridine Synergism on Enterobacteriaceae

J Michel 1, H Bornstein 1, R Luboshitzky 1, T Sacks 1
PMCID: PMC429238  PMID: 1155928

Abstract

A synergistic in vitro bactericidal effect of combinations of chloramphenicol and beta-lactams on strains of Enterobacteriaceae is described. The synergism is seen with strains which are resistant to the beta-lactam and is due to chloramphenicol-induced inhibition of beta-lactamase production.

Full text

PDF
845

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHABBERT Y. Une technique nouvelle d'étude de l'action bactéricide des associations d'antibiotiques: le transfert sur cellophane. Ann Inst Pasteur (Paris) 1957 Sep;93(3):289–299. [PubMed] [Google Scholar]
  2. CITRI N. DETERMINATION OF PENICILLINASE ACTIVITY. Methods Med Res. 1964;10:221–232. [PubMed] [Google Scholar]
  3. Cluzel R., Michel J., Cluzel M., Sirot J. Les modalités de la diffusion en gélose des antibiotiques dans la disposition en croix dérivée du transfert sur cellophane. C R Seances Soc Biol Fil. 1970;164(4):807–812. [PubMed] [Google Scholar]
  4. Finland M. Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis. 1970 Nov;122(5):419–431. doi: 10.1093/infdis/122.5.419. [DOI] [PubMed] [Google Scholar]
  5. GARROD L. P., WATERWORTH P. M. Methods of testing combined antibiotic bactericidal action and the significance of the results. J Clin Pathol. 1962 Jul;15:328–338. doi: 10.1136/jcp.15.4.328. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldner M., Glass D. G., Fleming P. C. Characteristics of Aerobacter beta-lactamase. Can J Microbiol. 1968 Feb;14(2):139–145. doi: 10.1139/m68-023. [DOI] [PubMed] [Google Scholar]
  7. Kabins S. A., Nathan C. R., Cohen S. R factor-mediated resistance to gentamicin in a clinical isolate of Escherichia coli. J Infect Dis. 1971 Dec;124 (Suppl):S65–S69. doi: 10.1093/infdis/124.supplement_1.s65. [DOI] [PubMed] [Google Scholar]
  8. Luboshitzky R., Sacks T., Michel J. Bactericidal effect of combinations of antibiotics on Klebsiella-Enterobacter-Serratia. Chemotherapy. 1973;19(6):354–366. doi: 10.1159/000221476. [DOI] [PubMed] [Google Scholar]
  9. Lund M. E., Blazevic D. J., Matsen J. M. Rapid gentamicin bioassay using a multiple-antibiotic-resistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother. 1973 Nov;4(5):569–573. doi: 10.1128/aac.4.5.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MANTEN A., WISSE M. J. Antagonism between antibacterial drugs. Nature. 1961 Nov 18;192:671–672. doi: 10.1038/192671a0. [DOI] [PubMed] [Google Scholar]
  11. Michel J., Luboshitzky R., Sacks T. Bactericidal effect of combinations of nalidixic acid and various antibiotics on Enterobacteriaceae. Antimicrob Agents Chemother. 1973 Sep;4(3):201–204. doi: 10.1128/aac.4.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Onishi H. R., Daoust D. R., Zimmerman S. B., Hendlin D., Stapley E. O. Cefoxitin, a semisynthetic cephamycin antibiotic: resistance to beta-lactamase inactivation. Antimicrob Agents Chemother. 1974 Jan;5(1):38–48. doi: 10.1128/aac.5.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Seneca H. Drug susceptibility-resistance pattern of gram-negative uropathogens to seven cephalosporins. Am J Med Sci. 1973 Nov;266(5):381–385. doi: 10.1097/00000441-197311000-00005. [DOI] [PubMed] [Google Scholar]
  14. Traub W. H. In vitro activity of chloramphenicol combined with cephalothin against D-Nase-positive, multiple-antibiotic resistant strains of Staphylococcus epidermidis. Chemotherapy. 1970;15(4):234–241. doi: 10.1159/000220687. [DOI] [PubMed] [Google Scholar]
  15. Workman R. G., Farrar W. E., Jr Activity of penicillinase in Staphylococcus aureus as studied by the iodometric method. J Infect Dis. 1970 Apr;121(4):433–437. doi: 10.1093/infdis/121.4.433. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES