Abstract
Cycloheximide accumulation in a fermentation medium has been shown to be the product of the balance between synthesis and degradation of this antibiotic. Glucose has been shown to prevent cycloheximide degradation. Cycloheximide has been shown to interfere with its own synthesis probably due to feedback inhibition. Approaches for increasing cycloheximide titers in the light of these findings are discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Kominek L. A. Cycloheximide production by Streptomyces griseus: alleviation of end-product inhibition by dialysis-extraction fermentation. Antimicrob Agents Chemother. 1975 Jun;7(6):861–863. doi: 10.1128/aac.7.6.861. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Malik V. S., Vining L. C. Metabolism of chloramphenicol by the producing organism. Can J Microbiol. 1970 Mar;16(3):173–179. doi: 10.1139/m70-030. [DOI] [PubMed] [Google Scholar]
- Spízek J., Málek I., Suchý J., Vondrácek M., Vanek Z. Metabolites of Streptomyces noursei. V. Relation of the production of cycloheximide and actiphenol to the production of fungicidin. Folia Microbiol (Praha) 1965 Sep;10(5):263–266. doi: 10.1007/BF02871023. [DOI] [PubMed] [Google Scholar]
- Vanek Z., Půza M., Cudlín J., Vondrácek M., Rickards R. W. Metabolites of Streptomyces noursei. X. Biogenesis of cycloheximide. Folia Microbiol (Praha) 1969;14(4):388–397. doi: 10.1007/BF02872708. [DOI] [PubMed] [Google Scholar]