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. 1975 Jul;8(1):1–4. doi: 10.1128/aac.8.1.1

Inhibition of Ribosomal A Site Functions by Sporangiomycin and Micrococcin

Eric Cundliffe 1, Peter D Dixon 1
PMCID: PMC429249  PMID: 809000

Abstract

Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [35S]thiostrepton for ribosomal binding sites. We conclude that micrococcin and sporangiomycin block the ribosomal A site in the vicinity of the complex guanosine triphosphatase center and so resemble thiostrepton in their modes of action.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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