Abstract
The antibacterial activities of nitropyrroles, nitrothiophenes, and aminothiophenes were studied. Replacement of the nitro group with an amino group enhanced the activity of the thiophene compounds.
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- ASNIS R. E. The reduction of Furacin by cell-free extracts of Furacin-resistant and parent-susceptible strains of Escherichia coli. Arch Biochem Biophys. 1957 Jan;66(1):208–216. doi: 10.1016/0003-9861(57)90551-9. [DOI] [PubMed] [Google Scholar]
- Cohen S. M., Lower G. M., Jr, Ertürk E., Bryan G. T. Comparative carcinogenicity in Swiss mice of N-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide and structurally related 5-nitrofurans and 4-nitrobenzenes. Cancer Res. 1973 Jul;33(7):1593–1597. [PubMed] [Google Scholar]
- Colwell W. T., Lange J. H., Henry D. W. Chemotherapeutic nitroheterocycles. Nitropyrrole-2-carboxaldehyde derivatives. J Med Chem. 1968 Mar;11(2):282–285. doi: 10.1021/jm00308a021. [DOI] [PubMed] [Google Scholar]
- EBETINO F. F., CARROLL J. J., GEVER G. REDUCTION OF NITROFURANS. I. AMINOFURANS. J Med Pharm Chem. 1962 May;91:513–524. doi: 10.1021/jm01238a011. [DOI] [PubMed] [Google Scholar]
- Feller D. R., Morita M., Gillette J. R. Enzymatic reduction of niridazole by rat liver microsomes. Biochem Pharmacol. 1971 Jan;20(1):203–215. doi: 10.1016/0006-2952(71)90486-2. [DOI] [PubMed] [Google Scholar]
- Grunberg E., Titsworth E. H. Chemotherapeutic properties of heterocyclic compounds: monocyclic compounds with five-membered rings. Annu Rev Microbiol. 1973;27:317–346. doi: 10.1146/annurev.mi.27.100173.001533. [DOI] [PubMed] [Google Scholar]
- McCalla D. R., Reuvers A., Kaiser C. Mode of action of nitrofurazone. J Bacteriol. 1970 Dec;104(3):1126–1134. doi: 10.1128/jb.104.3.1126-1134.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miura K., Reckendorf H. K. The nitrofurans. Prog Med Chem. 1967;5:320–381. doi: 10.1016/s0079-6468(08)70446-6. [DOI] [PubMed] [Google Scholar]
- TAYLOR J. D., PAUL H. E., PAUL M. F. Metabolism of the nitrofurans. III. Studies with xanthine oxidase in vitro. J Biol Chem. 1951 Jul;191(1):223–231. [PubMed] [Google Scholar]
- Yahagi T., Nagao M., Hara K., Matsushima T., Sugimura T., Bryan G. T. Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive. Cancer Res. 1974 Sep;34(9):2266–2273. [PubMed] [Google Scholar]