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. 1975 Sep;8(3):262–265. doi: 10.1128/aac.8.3.262

Paradoxical Action of Penicillin G on Staphylococcus aureus: a Time Study of the Effect of a Zonal Antibiotic Concentration Gradient on Bacterial Growth

E Yourassowsky 1, M P Vanderlinden 1, M J Lismont 1, E Schoutens 1
PMCID: PMC429303  PMID: 1167041

Abstract

The killing rate of a zonal concentration gradient of penicillin G on Staphylococcus aureus was studied by using a previously described triple-layer technique, enzymatic inactivation of the antibiotic, and an automatic image analyzer. This gradient determines a target image, whose center is the reservoir of antibiotic (constituted by a paper disk containing 100 U of penicillin G) and whose successive concentric zones are: a zone of slow bactericidal activity (corresponding to high levels of penicillin G), a zone of maximal bactericidal activity (corresponding to optimal levels of penicillin G), and a zone of overgrowth situated in front of the antibiotic wave.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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