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. 1975 Sep;8(3):370–376. doi: 10.1128/aac.8.3.370

Genetic and Physiological Studies on the Site of Action of Distamycin A

A G Siccardi 1, E Lanza 1, E Nielsen 1, A Galizzi 1, G Mazza 1
PMCID: PMC429320  PMID: 810085

Abstract

Two new genetic loci of Bacillus subtilis are identified by mutations that confer resistance to distamycin A and to other antibacterial agents. The chromosomal region where they map probably contains a cluster of genes whose products are related to membrane structure and function. Some of the biological effects of distamycin A are still in evidence in the resistant mutants indicating that the drug possibly acts at multiple sites. Most biological effects of the drug (including the phenotypic correction of a morphopoietic mutation) are likely to be due to the interaction of distamycin A with membrane (or surface) structures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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