Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1975 Oct;8(4):391–395. doi: 10.1128/aac.8.4.391

Mineral Nutrition of Streptomyces kanamyceticus for Kanamycin Formation

Ketaki Basak 1, S K Majumdar 1
PMCID: PMC429353  PMID: 1190749

Abstract

Kanamycin production by Streptomyces kanamyceticus ATCC 12853 requires magnesium sulfate and potassium phosphate at concentrations of 0.4 and 1.0 g per liter, respectively. The optimal concentrations of Fe and Zn for production of kanamycin are 0.25 and 0.575 μg/ml, respectively, whereas Mo at 0.04 μg/ml allows maximal cellular growth and antibiotic synthesis. Mn and Ca are without any effect. Cu, Co, Ni, and V have inhibitory effect on growth of the organism as well as kanamycin formation.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ACKER R. F., LECHEVALIER H. Some nutritional requirements of Streptomyces griseus 3570 for growth and candicidin production. Appl Microbiol. 1954 May;2(3):152–157. doi: 10.1128/am.2.3.152-157.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Basak K., Majumdar S. K. Utilization of carbon and nitrogen sources by Streptomyces kanamyceticus for kanamycin production. Antimicrob Agents Chemother. 1973 Jul;4(1):6–10. doi: 10.1128/aac.4.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHESTERS C. G. C., ROLINSON G. N. Trace elements and streptomycin production. J Gen Microbiol. 1951 Aug;5(3):559–565. doi: 10.1099/00221287-5-3-559. [DOI] [PubMed] [Google Scholar]
  4. DONALD C., PASSEY B. I., SWABY R. J. A comparison of methods for removing trace metals from microbiological media. J Gen Microbiol. 1952 Nov;7(3-4):211–220. doi: 10.1099/00221287-7-3-4-211. [DOI] [PubMed] [Google Scholar]
  5. KATZ E., PIENTA P., SIVAK A. The role of nutrition in the synthesis of actinomycin. Appl Microbiol. 1958 Jul;6(4):236–241. doi: 10.1128/am.6.4.236-241.1958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Koffler H., Knight S. G., Frazier W. C. The Effect of Certain Mineral Elements on the Production of Penicillin in Shake Flasks. J Bacteriol. 1947 Jan;53(1):115–123. doi: 10.1128/jb.53.1.115-123.1947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MAJUMDAR M. K., MAJUMDAR S. K. EFFECTS OF MINERALS ON NEOMYCIN PRODUCTION BY STREPTOMYCES FRADIAE. Appl Microbiol. 1965 Mar;13:190–193. doi: 10.1128/am.13.2.190-193.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MAJUMDAR S. K., BOSE S. K. Trace element requirements of Bacillus subtilis for mycobacillin formation. J Bacteriol. 1960 Apr;79:564–565. doi: 10.1128/jb.79.4.564-565.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Majumdar M. K., Majumdar S. K. Utilization of carbon and nitrogen-containing compounds for neomycin production by Streptomyces fradiae. Appl Microbiol. 1967 Jul;15(4):744–749. doi: 10.1128/am.15.4.744-749.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reynolds D. M., Waksman S. A. Grisein, an Antibiotic Produced by Certain Strains of Streptomyces griseus. J Bacteriol. 1948 May;55(5):739–752. doi: 10.1128/jb.55.5.739-752.1948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. STEINBERG R. A. Trace element impurities in nutrient solutions for fungi. Arch Biochem. 1950 Aug;28(1):111–116. [PubMed] [Google Scholar]
  12. UMEZAWA H., UEDA M., MAEDA K., YAGISHITA K., KONDO S., OKAMI Y., UTAHARA R., OSATO Y., NITTA K., TAKEUCHI T. Production and isolation of a new antibiotic: kanamycin. J Antibiot (Tokyo) 1957 Sep;10(5):181–188. [PubMed] [Google Scholar]
  13. WEBLEY D. M. The effect of deficiency of iron, zinc and manganese on the growth and morphology of Nocardia opaca. J Gen Microbiol. 1960 Aug;23:87–92. doi: 10.1099/00221287-23-1-87. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES