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. 1975 Oct;8(4):468–473. doi: 10.1128/aac.8.4.468

Inhibition of Experimental Deoxyribonucleic Acid Virus-Induced Encephalitis by 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate

Lois B Allen 1, Jodia M Thompson 1, John H Huffman 1, Ganapathi R Revankar 1, Richard L Tolman 1, Lionel N Simon 1, Roland K Robins 1, Robert W Sidwell 1
PMCID: PMC429374  PMID: 172008

Abstract

9-β-d-Arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP) significantly controlled the development of encephalitis produced by deoxyribonucleic acid viruses in mice. In most experiments the activities of ara-HxMP and 9-β-d-arabinofuranosyladenine (ara-A) were determined simultaneously. In the intracerebral (target organ) and intravenous therapy experiments, ara-HxMP had a pronounced advantage over ara-A since the water solubility of ara-HxMP enabled it to be used in much higher concentrations. In experiments where the two drugs were administered intraperitoneally or orally they exhibited similar activity. In several intraperitoneal therapy experiments ara-HxMP was tested alone, using various treatment schedules and dosages. In these experiments, efficacy was observed in groups that had treatments initiated as late as 72 h after virus inoculation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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