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. 1975 Oct;8(4):474–478. doi: 10.1128/aac.8.4.474

Efficacy of 9-β-d-Arabinofuranosylhypoxanthine 5′-Monophosphate in Therapy of Equine Abortion Virus-Induced Hepatitis in Hamsters1

Lois B Allen 1, John H Huffman 1, Ganapathi R Revankar 1, Robert L Tolman 1, Lionel N Simon 1, Roland K Robins 1, Robert W Sidwell 1
PMCID: PMC429375  PMID: 172009

Abstract

Equine abortion virus (EAV)-induced hepatitis in hamsters presents an interesting animal model for the evaluation of drugs possessing anti-deoxyribonucleic acid virus activity. These experiments demonstrate that 9-β-d-arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP), a new synthetic, water-soluble, antiviral agent, effectively controls this disease in hamsters with a therapeutic index of ∼60. Ara-HxMP prevented hepatitis-associated deaths in hamsters, reduced the titer of EAV developing in hamsters, and inhibited the increase of serum glutamic pyruvic transaminase in EAV-infected hamsters.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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