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. 1975 Nov;8(5):532–537. doi: 10.1128/aac.8.5.532

Pharmacokinetics of Minocycline in Renal Failure

P G Welling †, W R Shaw †, S J Uman †, F L S Tse †, W A Craig *
PMCID: PMC429414  PMID: 1211910

Abstract

The pharmacokinetics of minocycline have been studied after single intravenous infusions and repeated oral doses to human subjects with varying degrees of renal impairment. There was no evidence of reduced drug clearance with reduced renal function after intravenous doses although there appeared to be an increase in the tissue distribution of antibiotic in the body in uremia. After identical multiple oral dosage regimens serum levels of antibiotic were comparable in normal and mildly uremic subjects. There was no evidence of renal toxicity in normal or uremic subjects with the repeated dosage regimen used.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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