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. 2014 Oct 16;5(22):11442–11451. doi: 10.18632/oncotarget.2556

Figure 4. Expression of senescence-associated genes after oxaliplatin treatment in vivo and in vitro.

Figure 4

Tumor bearing rats were treated with oxaliplatin or saline solution (control) at day 21. (A) At days 22 or 29, tumors were harvested and IFN-γ, IL-1β and TNF-α concentrations were determined by ELISA. (B) Ninety six hours later injection, tumors were harvested and expression level of il-6, il-8 and mmp3 mRNAs was determined by RT-PCR and normalized to gapdh gene expression. Bars are means ± SEM. Significant differences were determined by Mann-Whitney U test. *p < 0.05.