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. 2014 Oct 24;5(22):11428–11441. doi: 10.18632/oncotarget.2552

Table 1. Associations of clinicopathological features with MTAP immunoexpression and gene status in primary myxofibrosarcomas.

MTAP Expression (n=87) p-value MTAP Gene (n=79) p-value
Deficient Positive HD Non-HD
Sex 1.000 0.936
 Male 18 31 8 23
 Female 14 24 12 36
Age 1.000 0.854
 <60 years 12 21 23 7
 ≥60 years 20 30 37 13
Location 0.799 0.908
 Extremity 23 42 15 45
 Axial 9 13 5 14
Tumor necrosis 0.483 0.115
 <10% 19 38 41 10
 >=10% 13 17 18 10
FNCLCC grade 0.534 0.006*
 grade 1 13 25 30 4
 grade 2 12 23 24 9
 grade 3 7 7 5 7
AJCC stage 0.763 0.097
 Stage 1 6 14 16 1
 Stage 2 12 19 21 9
 Stage 3 13 20 20 10
Tumor size& 7.314±6.528 6.347±3.701 0.633 6.600 4.808 7.311 5.551 0.612
Mitotic rate& 12.81±13.143 10.33±1.695 0.585 8.780±9.180 19.050±15.408 0.011*
MTAP gene status <0.001
 Aberration (HD, PM) 26 (16,10) 4 (4,0)
 No aberration (no HD or PM detected) 3 46

HD: homozygous deletion, PM: promoter methylation,

*

:Statistically significant,

&

:t-test,