Abstract
The antibiotic activity was determined at different intervals of time on plasma samples, taken from rats treated with a certain number of commonly used antibiotics, and kept at −20 C up to 8 weeks. The results of the microbiological assays demonstrate that the stability of the antibiotics in the frozen plasma decreases in the following order: oxytetracycline > cephalexin, streptomycin, erythromycin > demeclocycline > ampicillin, amoxycillin > penicillin G, cephaloridine, rolitetracycline, and tetracycline.
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Selected References
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- Boylan J. C., Simmons J. L., Winely C. L. Stability of frozen solutions of sodium cephalothin and cephaloridine. Am J Hosp Pharm. 1972 Aug;29(8):687–689. [PubMed] [Google Scholar]
- Bramanti G., Ravina A., De Fina V. Conservabilita' del siero di ratto nel caso di determinazioni differite nel tempo di alcuni parametri ematochimici. Boll Chim Farm. 1972 Nov;111(11):694–699. [PubMed] [Google Scholar]
- Hou J. P., Poole J. W. Kinetics and mechanism of degradation of ampicillin in solution. J Pharm Sci. 1969 Apr;58(4):447–454. doi: 10.1002/jps.2600580412. [DOI] [PubMed] [Google Scholar]
- Hussar D. A., Niebergall P. J., Sugita E. T., Doluisio J. T. Aspects of the epimerization of certain tetracycline derivatives. J Pharm Pharmacol. 1968 Jul;20(7):539–546. doi: 10.1111/j.2042-7158.1968.tb09802.x. [DOI] [PubMed] [Google Scholar]
- Kuchinskas E. J., Levy G. N. Comparative stabilities of ampicillin and hetacillin in aqueous solution. J Pharm Sci. 1972 May;61(5):727–729. doi: 10.1002/jps.2600610511. [DOI] [PubMed] [Google Scholar]
- Leeson L. J., Weidenheimer J. F. Stability of tetracycline and riboflavin. J Pharm Sci. 1969 Mar;58(3):355–357. doi: 10.1002/jps.2600580315. [DOI] [PubMed] [Google Scholar]
- Saccani F., Pansera F. Stabilità' dell'ampicillina e della etacillina. Boll Chim Farm. 1968 Oct;107(10):640–648. [PubMed] [Google Scholar]
- Savello D. R., Shangraw R. F. Stability of sodium ampicillin solutions in the frozen and liquid states. Am J Hosp Pharm. 1971 Oct;28(10):754–759. [PubMed] [Google Scholar]
- Schwartz M. A., Hayton W. L. Relative stability of hetacillin and ampicillin in solution. J Pharm Sci. 1972 Jun;61(6):906–909. doi: 10.1002/jps.2600610616. [DOI] [PubMed] [Google Scholar]
- Walton V. C., Howlett M. R., Selzer G. B. Anhydrotetracycline and 4-epianhydrotetracycline in market tetracyclines and aged tetracycline products. J Pharm Sci. 1970 Aug;59(8):1160–1164. doi: 10.1002/jps.2600590822. [DOI] [PubMed] [Google Scholar]
- Whyatt P. L., Dann R. E., Slywka G. W., Meyer M. C. Rapid, precise, turbidometric assay for low levels of ampicillin in serum after single-dose oral administration. Antimicrob Agents Chemother. 1974 Dec;6(6):811–814. doi: 10.1128/aac.6.6.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yamana T., Tsuji A., Kanayama K., Nakano O. Comparative stabilities of cephalosporins in aqueous solution. J Antibiot (Tokyo) 1974 Dec;27(12):1000–1002. doi: 10.7164/antibiotics.27.1000. [DOI] [PubMed] [Google Scholar]
- de Traverse P. M., Henrotte J. G., Depraitère R. Etude de la conservation des échantillons de plasma et de sérum destinés aux analyses biologiques. Sem Hop. 1969 Jun 8;45(27):1907–1907. [PubMed] [Google Scholar]
