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. 1975 Dec;8(6):684–687. doi: 10.1128/aac.8.6.684

Evaluation of a Topical Interferon Inducer in Experimental Influenza Infection in Volunteers

R Gordon Douglas Jr 1, Robert F Betts 1, Ruth L Simons 1, Patricia W Hogan 1, Frieda K Roth 1
PMCID: PMC429448  PMID: 1211921

Abstract

The prophylactic and/or therapeutic effect of a low-molecular-weight interferon inducer, CP-20,961, was tested in a double-blind placebo controlled study of experimental influenza A/England/42/72 (H3N2) infection in normal volunteers. Ten volunteers received CP-20,961 and 10 received placebo. Interferon was detected in nasal secretions of nine of the former and three of the latter group (P < 0.05). Seven in each group became ill, and severity of illness was not different. Also, quantitative virus shedding patterns and antibody response were not different between the two groups. The negative result may have been due to the relatively low quantities of interferon induced.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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