Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1975 Dec;8(6):757–758. doi: 10.1128/aac.8.6.757

Comparison of the Antibacterial Activities of Sisomicin and Gentamicin Against Gram-Negative Bacteria

Burt R Meyers 1, Bernard Leng 1, Shalom Z Hirschman 1
PMCID: PMC429460  PMID: 1211927

Abstract

Sisomicin was found to be more active on a weight basis than gentamicin against Pseudomonas sp., Klebsiella sp., and indole-positive Proteus. Gentamicin was more active than sisomicin against Escherichia coli, Serratia sp., Enterobacter sp., and Proteus mirabilis. Both antibiotics were very active against methicillin-resistant strains of Staphylococcus aureus.

Full text

PDF
757

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  2. Crowe C. C., Sanders E. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3(1):24–28. doi: 10.1128/aac.3.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hyams P. J., Simberkoff M. S., Rahal J. J., Jr In vitro bactericidal effectiveness of four aminoglycoside antibiotics. Antimicrob Agents Chemother. 1973 Jan;3(1):87–94. doi: 10.1128/aac.3.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Rodriguez V., Bodey G. P., Valdivieso M., Feld R. Clinical pharmacology of sisomicin. Antimicrob Agents Chemother. 1975 Jan;7(1):38–41. doi: 10.1128/aac.7.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Waitz J. A., Moss E. L., Jr, Drube C. G., Weinstein M. J. Comparative activity of sisomicin, gentamicin, kanamycin, and tobramycin. Antimicrob Agents Chemother. 1972 Dec;2(6):431–437. doi: 10.1128/aac.2.6.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Young L. S., Hewitt W. L. Activity of five aminoglycoside antibiotics in vitro against gram-negative bacilli and Staphylococcus aureus. Antimicrob Agents Chemother. 1973 Dec;4(6):617–625. doi: 10.1128/aac.4.6.617. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES