Abstract
Two plasmid-linked tetracycline resistance characters, tet A and tet B, were distinguishable in part, according to the level of resistance they conferred to minocycline (<3 μg/ml for tet A; >6 μg/ml for tet B). Escherichia coli K-12 strains that harbored the tet B character were also resistant to tetracycline but susceptible to chelocardin. In such tet B strains, subinhibitory concentrations of tetracycline could induce resistance to chelocardin as well as to otherwise inhibitory concentrations of tetracyclines. Chelocardin itself was ineffective as an inducer and therefore could be used to select constitutively resistant mutants. E. coli K-12 strains harboring the tet A character were also resistant to tetracycline and susceptible to chelocardin; tetracycline did not induce resistance to chelocardin in these strains.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARBER M., WATERWORTH P. M. ANTIBACTERIAL ACTIVITY OF LINCOMYCIN AND PRISTINAMYCIN: A COMPARISON WITH ERYTHROMYCIN. Br Med J. 1964 Sep 5;2(5409):603–606. doi: 10.1136/bmj.2.5409.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHABBERT Y. A., PATTE J. C. Cellophane transfer: application to the study of activity of combinations of antibiotics. Appl Microbiol. 1960 Jul;8:193–199. doi: 10.1128/am.8.4.193-199.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHABBERT Y. Antagonisme in vitro entre l'érythromycine et la spiramycine. Ann Inst Pasteur (Paris) 1956 Jun;90(6):787–790. [PubMed] [Google Scholar]
- Chabbert Y. A., Scavizzi M. R., Witchitz J. L., Gerbaud G. R., Bouanchaud D. H. Incompatibility groups and the classification of fi - resistance factors. J Bacteriol. 1972 Nov;112(2):666–675. doi: 10.1128/jb.112.2.666-675.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Franklin T. J. Resistance of Escherichia coli to tetracyclines. Changes in permeability to tetracyclines in Escherichia coli bearing transferable resistance factors. Biochem J. 1967 Oct;105(1):371–378. doi: 10.1042/bj1050371. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GARROD L. P. The erythromycin group of antibiotics. Br Med J. 1957 Jul 13;2(5036):57–63. doi: 10.1136/bmj.2.5036.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lai C. J., Weisblum B. Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus. Proc Natl Acad Sci U S A. 1971 Apr;68(4):856–860. doi: 10.1073/pnas.68.4.856. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATNEY T. S. New uses of membrane filters. I. The determination of the spontaneous mutation rate of Escherichia coli to streptomycin resistance. J Bacteriol. 1955 Jan;69(1):101–102. doi: 10.1128/jb.69.1.101-102.1955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mao J. C., Robishaw E. E. Mode of action of beta-chelocardin. Biochim Biophys Acta. 1971 Apr 29;238(1):157–160. doi: 10.1016/0005-2787(71)90019-0. [DOI] [PubMed] [Google Scholar]
- SZYBALSKI W., BRYSON V. Genetic studies on microbial cross resistance to toxic agents. I. Cross resistance of Escherichia coli to fifteen antibiotics. J Bacteriol. 1952 Oct;64(4):489–499. doi: 10.1128/jb.64.4.489-499.1952. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scavizzi M. R. Existence de deux caractères transférables de résistance aux tétracyclines. Ann Inst Pasteur (Paris) 1972 Jan;122(1):3–17. [PubMed] [Google Scholar]
- Weisblum B., Siddhikol C., Lai C. J., Demohn V. Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction. J Bacteriol. 1971 Jun;106(3):835–847. doi: 10.1128/jb.106.3.835-847.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]