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. 1976 Jan;9(1):128–130. doi: 10.1128/aac.9.1.128

Induction of Erythromycin Resistance in Staphylococcus aureus by Erythromycin Derivatives

Sidney Pestka *, Robert Vince , Ronald LeMahieu , Florence Weiss , Lucille Fern , Joel Unowsky
PMCID: PMC429486  PMID: 1259386

Abstract

The ability of 53 erythromycin analogues to induce resistance to erythromycin in Staphlococcus aureus was evaluated. Only derivatives with antibacterial activity induced resistance, although some antibacterial compounds did not induce resistance. No derivatives without antibacterial activity but with ability to induce resistance were found.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHABBERT Y. Antagonisme in vitro entre l'érythromycine et la spiramycine. Ann Inst Pasteur (Paris) 1956 Jun;90(6):787–790. [PubMed] [Google Scholar]
  2. Hashimoto H., Oshima H., Mitsuhashi S. Drug resistance of staphylococci. IX. Inducible resistance to macrolide antibiotics in Staphylococcus aureus. Jpn J Microbiol. 1968 Sep;12(3):321–327. [PubMed] [Google Scholar]
  3. Kono M., Hashimoto H., Mitsuhashi S. Drug resistance to staphylococci. 3. Resistance to some macrolide antibiotics and inducible system. Jpn J Microbiol. 1966 Apr;10(1):59–66. [PubMed] [Google Scholar]
  4. Lai C. J., Dahlberg J. E., Weisblum B. Structure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureus. Biochemistry. 1973 Jan 30;12(3):457–460. doi: 10.1021/bi00727a015. [DOI] [PubMed] [Google Scholar]
  5. Lai C. J., Weisblum B. Altered methylation of ribosomal RNA in an erythromycin-resistant strain of Staphylococcus aureus. Proc Natl Acad Sci U S A. 1971 Apr;68(4):856–860. doi: 10.1073/pnas.68.4.856. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lai C. J., Weisblum B., Fahnestock S. R., Nomura M. Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus. J Mol Biol. 1973 Feb 15;74(1):67–72. doi: 10.1016/0022-2836(73)90355-0. [DOI] [PubMed] [Google Scholar]
  7. Malke H. Genetics of resistance to macrolide antibiotics and lincomycin in natural isolates of Streptococcus pyogenes. Mol Gen Genet. 1974;135(4):349–367. doi: 10.1007/BF00271149. [DOI] [PubMed] [Google Scholar]
  8. Pestka S., Lemahieu R. A. Effect of erythromycin analogues on binding of [14C]erythromycin to Escherichia coli ribosomes. Antimicrob Agents Chemother. 1974 Oct;6(4):479–488. doi: 10.1128/aac.6.4.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pestka S., Lemahieu R., Miller P. Correlation of effects of erythromycin analogues on intact bacteria and on [14C]erythromycin binding to Escherichia coli ribosomes. Antimicrob Agents Chemother. 1974 Oct;6(4):489–491. doi: 10.1128/aac.6.4.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Tanaka T., Weisblum B. Mutant of Staphylococcus aureus with lincomycin- and carbomycin-inducible resistance to erythromycin. Antimicrob Agents Chemother. 1974 May;5(5):538–540. doi: 10.1128/aac.5.5.538. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Vince R., Weiss D., Pestka S. Binding of N-substituted erythromycyclamines to ribosomes. Antimicrob Agents Chemother. 1976 Jan;9(1):131–136. doi: 10.1128/aac.9.1.131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. WEAVER J. R., PATTEE P. A. INDUCIBLE RESISTANCE TO ERYTHROMYCIN IN STAPHYLOCOCCUS AUREUS. J Bacteriol. 1964 Sep;88:574–580. doi: 10.1128/jb.88.3.574-580.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Weisblum B., Demohn V. Erythromycin-inducible resistance in Staphylococcus aureus: survey of antibiotic classes involved. J Bacteriol. 1969 May;98(2):447–452. doi: 10.1128/jb.98.2.447-452.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Weisblum B., Siddhikol C., Lai C. J., Demohn V. Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction. J Bacteriol. 1971 Jun;106(3):835–847. doi: 10.1128/jb.106.3.835-847.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Yag Y., Franke A. E., Clewell D. B. Plasmid-determined resistance to erythromycin: comparison of strains of streptococcus faecalis and streptococcus pyogenes with regard to plasmid hmology and resistance inducibility. Antimicrob Agents Chemother. 1975 Jun;7(6):871–873. doi: 10.1128/aac.7.6.871. [DOI] [PMC free article] [PubMed] [Google Scholar]

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