Abstract
Serum and urine concentrations were measured after administration of 0.5-and 1-g doses of cefamandole intramuscularly and intravenously to healthy volunteers. Intramuscular doses of 0.5 and 1 g yielded serum concentrations at 1 h of 14.7 and 35.6 μg/ml, respectively. Significant antibacterial concentrations persisted through h 8. Intravenous doses of 0.5 and 1 g resulted in respective peak serum levels of 21 μg/ml at 45 min and 103 μg/ml at 15 min; these serum levels rapidly declined. Very high urine concentrations were achieved during the first 8 h after injection.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Eykyn S., Jenkins C., King A., Phillips I. Antibacterial activity of cefamandole, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin, and cephalexin. Antimicrob Agents Chemother. 1973 Jun;3(6):657–661. doi: 10.1128/aac.3.6.657. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyers B. R., Hirschman S. Z., Nicholas P. Cephanone: in vitro antibacterial activity and pharmacology in normal human volunteers. Antimicrob Agents Chemother. 1972 Oct;2(4):250–254. doi: 10.1128/aac.2.4.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meyers B. R., Leng B., Hirschman S. Z. Cefamandole: antimicrobial activity in vitro of a new cephalosporin. Antimicrob Agents Chemother. 1975 Dec;8(6):737–741. doi: 10.1128/aac.8.6.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C. Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity. Antimicrob Agents Chemother. 1974 Aug;6(2):177–182. doi: 10.1128/aac.6.2.177. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nicholas P., Meyers B. R., Hirschman S. Z. Cephalexin: pharmacologic evaluation following oral and parenteral administration. J Clin Pharmacol. 1973 Nov-Dec;13(11):463–468. doi: 10.1002/j.1552-4604.1973.tb00200.x. [DOI] [PubMed] [Google Scholar]
- Nicholas P., Meyers B. R., Hirschman S. Z. Pharmacology of cefazolin in human volunteers. J Clin Pharmacol. 1973 Aug-Sep;13(8):325–331. doi: 10.1002/j.1552-4604.1973.tb00219.x. [DOI] [PubMed] [Google Scholar]
- Wick W. E., Preston D. A. Biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics. Antimicrob Agents Chemother. 1972 Mar;1(3):221–234. doi: 10.1128/aac.1.3.221. [DOI] [PMC free article] [PubMed] [Google Scholar]