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. 1976 Feb;9(2):224–232. doi: 10.1128/aac.9.2.224

Biogenetic Origin of the d-Isoleucine and N-Methyl-l-Alloisoleucine Residues in the Actinomycins

Takehiko Yajima a,1, Kaarin Mason a, Edward Katz a
PMCID: PMC429508  PMID: 57739

Abstract

Studies with 14C-labeled isoleucine stereisomers have established that l-alloisoleucine, d-alloisoleucine, and d-isoleucine may function as precursors for the biogenesis of d-isoleucine and N-methyl-l-alloisoleucine residues in actinomycin. l-[14C]isoleucine appears to be employed chiefly for d-alloisoleucine (and N-methylisoleucine [?] formation); however, its role in the biosynthesis of d-isoleucine and N-methylalloisoleucine remains unclear. The potential pathway of biosynthesis of d-isoleucine and N-methyl-l-isoleucine is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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