Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1976 Feb;9(2):312–317. doi: 10.1128/aac.9.2.312

Hyperbaric Oxygen Exposures for Intrahepatic Abscesses Produced in Mice by Nonsporeforming Anaerobic Bacteria

Gale B Hill 1
PMCID: PMC429520  PMID: 1267430

Abstract

Hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of Fusobacterium necrophorum plus either Bacteroides fragilis subsp. fragilis or Fusobacterium nucleatum in a mouse model. Infected control and hyperbaric oxygen-exposed mice were autopsied 5 or 6 weeks after inoculation of bacteria and were assigned numerical pathology scores according to the number and size of abscesses present. Seventeen daily 3-h exposures to 100% O2 at 2 atmospheres absolute pressure begun either 1 day or 1 week after injection of bacteria significantly reduced the number and size of abscesses among mice infected with either mixture of anaerobic organisms. Abscesses due to mixed fusobacteria were often completely resolved. These data support the efficacy of hyperbaric oxygen for treatment of mixed anaerobic infection produced by Bacteroides and Fusobacterium species and suggest its further evaluation as a potential alternate or adjunct to present therapy for certain types of serious anaerobic infection.

Full text

PDF
312

Images in this article

315Image
on p.315

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Finegold S. M., Bartlett J. G., Chow A. W., Flora D. J., Gorbach S. L., Harder E. J., Tally F. P. Management of anaerobic infections. Ann Intern Med. 1975 Sep;83(3):375–389. doi: 10.7326/0003-4819-83-3-375. [DOI] [PubMed] [Google Scholar]
  2. Finegold S. M., Rosenblatt J. E. Practical aspects of anaerobic sepsis. Medicine (Baltimore) 1973 Jul;52(4):311–322. doi: 10.1097/00005792-197307000-00010. [DOI] [PubMed] [Google Scholar]
  3. Gorbach S. L., Bartlett J. G. Anaerobic infections (second of three parts). N Engl J Med. 1974 May 30;290(22):1237–1245. doi: 10.1056/NEJM197405302902207. [DOI] [PubMed] [Google Scholar]
  4. Gorbach S. L., Bartlett J. G. Anaerobic infections (third of three parts). N Engl J Med. 1974 Jun 6;290(23):1289–1294. doi: 10.1056/NEJM197406062902305. [DOI] [PubMed] [Google Scholar]
  5. Gorbach S. L., Bartlett J. G. Anaerobic infections. 1. N Engl J Med. 1974 May 23;290(21):1177–1184. doi: 10.1056/NEJM197405232902106. [DOI] [PubMed] [Google Scholar]
  6. Hill G. B., Osterhout S. Experimental effects of hyperbaric oxgen on selected clostridial species. I. In-vitro studies. J Infect Dis. 1972 Jan;125(1):17–25. doi: 10.1093/infdis/125.1.17. [DOI] [PubMed] [Google Scholar]
  7. Hill G. B., Osterhout S. Experimental effects of hyperbaric oxygen on selected clostridial species. II. In-vitro studies in mice. J Infect Dis. 1972 Jan;125(1):26–35. doi: 10.1093/infdis/125.1.26. [DOI] [PubMed] [Google Scholar]
  8. Hill G. B., Osterhout S., O'Fallon W. M. Variation in response to hyperbaric oxygen among inbred strains of mice. Proc Soc Exp Biol Med. 1968 Dec;129(3):687–689. doi: 10.3181/00379727-129-33398. [DOI] [PubMed] [Google Scholar]
  9. Hill G. B., Osterhout S., Pratt P. C. Liver abscess production by non-spore-forming anaerobic bacteria in a mouse model. Infect Immun. 1974 Mar;9(3):599–603. doi: 10.1128/iai.9.3.599-603.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Holland J. A., Hill G. B., Wolfe W. G., Osterhout S., Saltzman H. A., Brown I. W., Jr Experimental and clinical experience with hyperbaric oxygen in the treatment of clostridial myonecrosis. Surgery. 1975 Jan;77(1):75–85. [PubMed] [Google Scholar]
  11. Manheim S. D., Voleti C., Ludwig A., Jacobson J. H., 2nd Hyperbaric oxygen in the treatment of actinomycosis. JAMA. 1969 Oct 20;210(3):552–553. [PubMed] [Google Scholar]
  12. Moore W. E., Cato E. P., Holdeman L. V. Anaerobic bacteria of the gastrointestinal flora and their occurrence in clinical infections. J Infect Dis. 1969 Jun;119(6):641–649. doi: 10.1093/infdis/119.6.641. [DOI] [PubMed] [Google Scholar]
  13. Sabbaj J., Sutter V. L., Finegold S. M. Anaerobic pyogenic liver abscess. Ann Intern Med. 1972 Oct;77(4):627–638. doi: 10.7326/0003-4819-77-4-629. [DOI] [PubMed] [Google Scholar]
  14. Schreiner A., Tönjum S., Digranes A. Hyperbaric oxygen therapy in bacteroides infections. Acta Chir Scand. 1974;140(1):73–76. [PubMed] [Google Scholar]
  15. VAN UNNIKA INHIBITION OF TOXIN PRODUCTION IN CLOSTRIDIUM PERFRINGENS IN VITRO BY HYPERBARIC OXYGEN. Antonie Van Leeuwenhoek. 1965;31:181–186. doi: 10.1007/BF02045889. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES