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. 1976 Feb;9(2):334–342. doi: 10.1128/aac.9.2.334

Evaluation of Antibiotic Efficacy Using Electron Microscopy: Morphological Effects of Guanylureido Cephalosporin, Chlorobenzoylureido Cephalosporin, BL-P1654, and Carbenicillin on Pseudomonas aeruginosa

L F Ellis 1, D K Herron 1, D A Preston 1, L K Simmons 1, R A Schlegel 1
PMCID: PMC429523  PMID: 817659

Abstract

The response of Pseudomonas aeruginosa to carbenicillin, BL-P1654, and two cephalosporins (112384 and 112883) was evaluated by minimal inhibitory concentration determinations, [14C]leucine uptake studies, morphological studies of colonial growth, and mouse intraperitoneal inoculations. Spheroplast formation and bacterial lysis were not the early response; instead, cell division was inhibited and long filaments were formed. Spheroplast formation and bacterial lysis were not observed in the first 7 h of incubation in minimal inhibitory concentrations of antibiotic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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