Abstract
In a screening program using the agar diffusion-plaque inhibition test, 22 out of 27 substituted aminopyrazoles tested showed marked antiviral activity against mengovirus in FL cell cultures. The efficacy of the different derivatives was compared by determining their effect on the yield of infectious virus after a one-step growth cycle. The antiviral activity against mengovirus correlated with the chain length of the substituents and increased or decreased according to the position of the side chain.
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Selected References
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- Montgomery J. A., Thomas H. J. Nucleosides of 2-azapurines and certain ring analogs. J Med Chem. 1972 Feb;15(2):182–187. doi: 10.1021/jm00272a014. [DOI] [PubMed] [Google Scholar]
- Roby R., Teskey C., Houlihan R. B. Inhibition of plaque formation by myxoma and fibroma viruses with pyrimidine analogues. Proc Soc Exp Biol Med. 1965 Nov;120(2):496–500. doi: 10.3181/00379727-120-30571. [DOI] [PubMed] [Google Scholar]
- Tonew E., Tonew M. Die Wirkung von Cycloheximid auf Abortus-Virus der Schafe, Sindbis-Virus und andere Viren in Screening-Untersuchungen. Zentralbl Bakteriol Orig. 1969;211(4):437–444. [PubMed] [Google Scholar]
- Tonew M., Tonew E. M. Antivirale Wirkung von Imidazolderivaten. I. Die Hemmung der Vermehrung des Mengovirus in FL-Zellen. Arch Gesamte Virusforsch. 1971;33(3):319–329. [PubMed] [Google Scholar]
- Veckenstedt A., Horn M. Testing of antiviral compounds against Mengo virus infection of mice. I. Screening of compounds and statistical evaluation of their effects. Chemotherapy. 1974;20(4):235–244. doi: 10.1159/000221813. [DOI] [PubMed] [Google Scholar]
- Witkowski J. T., Robins R. K., Sidwell R. W., Simon L. N. Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides. J Med Chem. 1972 Nov;15(11):1150–1154. doi: 10.1021/jm00281a014. [DOI] [PubMed] [Google Scholar]