Abstract
Candida spp. grown in synthetic medium supplemented with l-tryptophan as sole nitrogen source produced β-indoleethanol (β-IEA) and β-indolelactic acid (β-ILA). These compounds isolated from the culture filtrates were characterized by ultraviolet, infrared, and nuclear magnetic resonance spectral studies. Using dl-[3H]trypotophan in the medium, labeled β-IEA and β-ILA were isolated. Further, β-IEA was produced as a result incubating log-phase cells of C. albicans with β-ILA. Both β-IEA and β-ILA inhibited the growth of gram-positive and -negative bacteria. Autoantibiotic action of these compounds on Candida spp. and the reversal of this inhibition were studied.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bailey G. B., Gentile A. C. Indole Compounds Synthesized by Diplodia natalensis. Plant Physiol. 1962 May;37(3):439–445. doi: 10.1104/pp.37.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAPER J. M., VELDSTRA H. On the metabolism of tryptophan by Agrobacterium tumefaciens. Biochim Biophys Acta. 1958 Nov;30(2):401–420. doi: 10.1016/0006-3002(58)90065-9. [DOI] [PubMed] [Google Scholar]
- Lingappa B. T., Prasad M., Lingappa Y., Hunt D. F., Biemann K. Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans. Science. 1969 Jan 10;163(3863):192–194. doi: 10.1126/science.163.3863.192. [DOI] [PubMed] [Google Scholar]
- Narayanan T. K., Rao G. R. Production of 2-phenethyl alcohol and 2-phenyllactic acid in Candida species. Biochem Biophys Res Commun. 1974 Jun 4;58(3):728–735. doi: 10.1016/s0006-291x(74)80478-x. [DOI] [PubMed] [Google Scholar]
- Rigaud J. L'acide indolyl-3-lactique et son métabolisme chez Rhizobium. Arch Mikrobiol. 1970;72(4):297–307. [PubMed] [Google Scholar]
- Rigaud J. Synthèse d'acide indolyl-3-lactique et de tryptophol par Rhizobium cultivé en présence de tryptophane. C R Acad Sci Hebd Seances Acad Sci D. 1966 Jan 3;262(1):100–102. [PubMed] [Google Scholar]