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. 1976 Mar;9(3):397–405. doi: 10.1128/aac.9.3.397

In Vitro and Clinical Studies of Cefatrizine, a New Semisynthetic Cephalosporin

Ramon Del Busto 1, Erwin Haas 1, Tom Madhavan 1, Keith Burch 1, Frank Cox 1, Evelyn Fisher 1, Edward Quinn 1, Donald Pohlod 1
PMCID: PMC429543  PMID: 1259399

Abstract

Cefatrizine, a new oral semisynthetic cephalosporin, was evaluated in vitro and in the treatment of 18 patients with acute urinary tract infection, pneumonia, and soft tissue infection. In vitro, it was more active than cephalexin for gram-positive and gram-negative bacteria. It was also more active than cephalothin, cefazolin, and cephapirin against most of the gram-negative bacteria but less active against the gram-positive bacteria. Of the patients treated with cefatrizine, only one failed to respond. This patient had pneumococcal conjunctivitis and hypogammaglobulinemia and neutropenia. The mean peak serum level after multiple 6-hourly doses of 500 mg was 6.2 μg/ml. The serum levels of cefatrizine necessary for inhibition of most susceptible organisms were well within the achievable range. The drug was well tolerated, and no renal, hepatic, or hematological toxicity was detected.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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