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. 1976 Mar;9(3):540–543. doi: 10.1128/aac.9.3.540

In Vitro Susceptibility of Varicella Zoster Virus to Adenine Arabinoside and Hypoxanthine Arabinoside

Yvonne J Bryson 1, James D Connor 1
PMCID: PMC429566  PMID: 176937

Abstract

The in vitro susceptibility of varicella zoster (VZ) isolates to adenine arabinoside (ara-A) and hypoxanthine arabinoside (ara-Hx) was determined in human skin fibroblasts. Using a system in which deamination was inhibited, and using a modified plaque reduction method, the antiviral activities of ara-A and ara-Hx were separated. The plaque inhibitory concentration of ara-A for all VZ isolates tested was 1 to 2 μg/ml and 80 to 100 μg/ml for ara-Hx. A comparison of antiviral activity based upon total plaque suppression gave a rate of 40 to 50:1, in favor of ara-A.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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